ArticleScientific reports2017
Intraspecific differences in molecular stress responses and coral pathobiome contribute to mortality under bacterial challenge in Acropora millepora.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39 citing papers in PubMed.
- Algae-specific immune modulation influences responses to heat and pathogen challenge in a symbiotic coral.Science advances · 2026Article
- Resolving coral temperature vulnerability through heat and cold bleaching thresholds.Communications biology · 2025Article
- Coral thermotolerance retained following year-long exposure to a novel environment.Science advances · 2025Article
- Machine learning reveals distinct gene expression signatures across tissue states in stony coral tissue loss disease.Royal Society open science · 2025Article
- Connectivity and Adaptation Patterns of the Deep-Sea Ground-Forming Sponge Geodia hentscheli Across Its Entire Distribution.Molecular biology and evolution · 2025Article
- Transcriptomics of theEcology and evolution · 2025Article
- Prior heat stress increases pathogen susceptibility in the model cnidarian Exaiptasia diaphana.Communications biology · 2024Article
- Microbial and transcriptional response of Acropora valida and Turbinaria peltata to Vibrio coralliilyticus challenge: insights into corals disease resistance.BMC microbiology · 2024Article
- Intersection of coral molecular responses to a localized mortality event and ex situ deoxygenation.Ecology and evolution · 2024Article
- Synergistic response to climate stressors in coral is associated with genotypic variation in baseline expression.Proceedings. Biological sciences · 2024Article
- Physiological and biochemical responses of soft coral Sarcophyton trocheliophorum to doxycycline hydrochloride exposure.Scientific reports · 2023Article
- De novo assembly and annotation of the singing mouse genome.BMC genomics · 2023Article
- Review
- Stony coral tissue loss disease induces transcriptional signatures of in situ degradation of dysfunctional Symbiodiniaceae.Nature communications · 2023Article
- A homology guide for Pacific salmon genusEcology and evolution · 2023Article
- Symbioses are restructured by repeated mass coral bleaching.Science advances · 2022Article
- Mixtures of genotypes increase disease resistance in a coral nursery.Scientific reports · 2022Article
- Disease resistance in coral is mediated by distinct adaptive and plastic gene expression profiles.Science advances · 2022Article
- Mechanisms and potential immune tradeoffs of accelerated coral growth induced by microfragmentation.PeerJ · 2022Article
- Microscale tracking of coral-vibrio interactions.ISME communications · 2021Article
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6 authors.
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Abstract
Disease causes significant coral mortality worldwide; however, factors responsible for intraspecific variation in disease resistance remain unclear. We exposed fragments of eight Acropora millepora colonies (genotypes) to putatively pathogenic bacteria (Vibrio spp.). Genotypes varied from zero to >90% mortality, with bacterial challenge increasing average mortality rates 4-6 fold and shifting the microbiome in favor of stress-associated taxa. Constitutive immunity and subsequent immune and transcriptomic responses to the challenge were more prominent in high-mortality individuals, whereas low-mortality corals remained largely unaffected and maintained expression signatures of a healthier condition (i.e., did not launch a large stress response). Our results suggest that lesions appeared due to changes in the coral pathobiome (multiple bacterial species associated with disease) and general health deterioration after the biotic disturbance, rather than the direct activity of any specific pathogen. If diseases in nature arise because of weaknesses in holobiont physiology, instead of the virulence of any single etiological agent, environmental stressors compromising coral condition might play a larger role in disease outbreaks than is currently thought. To facilitate the diagnosis of compromised individuals, we developed and independently cross-validated a biomarker assay to predict mortality based on genes whose expression in asymptomatic individuals coincides with mortality rates.
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