Evidence map›Paper›PMID 28572671›Full record

ArticleScientific reports2017

Interaction studies of carbon nanomaterials and plasma activated carbon nanomaterials solution with telomere binding protein.

Pankaj Attri, Jitender Gaur, Sooho Choi, Minsup Kim, Rohit Bhatia, Naresh Kumar, Ji Hoon Park, Art E Cho, Eun Ha Choi, Weontae Lee

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Pankaj AttriPlasma Bioscience Research Center/Department of Electrical and Biological Physics, Kwangwoon University, Seoul, 139-701, Korea. chem.pankaj@gmail.com.
Jitender GaurDivision of Sustainable Technology, Rudraksh Proudhyogiki Sangathan, Delhi, India.
Sooho ChoiDepartment of Biochemistry, College of Life Science & Biotechnology, Yonsei University, Seoul, 120-749, Korea.
Minsup KimDepartment of Bioinformatics, Korea University, Sejong, 02841, Korea.
Rohit BhatiaDivision of Sustainable Technology, Rudraksh Proudhyogiki Sangathan, Delhi, India.
Naresh KumarPlasma Bioscience Research Center/Department of Electrical and Biological Physics, Kwangwoon University, Seoul, 139-701, Korea.
Ji Hoon ParkPlasma Bioscience Research Center/Department of Electrical and Biological Physics, Kwangwoon University, Seoul, 139-701, Korea.
Art E ChoDepartment of Bioinformatics, Korea University, Sejong, 02841, Korea.
Eun Ha ChoiPlasma Bioscience Research Center/Department of Electrical and Biological Physics, Kwangwoon University, Seoul, 139-701, Korea. ehchoi@kw.ac.kr.
Weontae LeeDepartment of Biochemistry, College of Life Science & Biotechnology, Yonsei University, Seoul, 120-749, Korea. wlee@spin.yonsei.ac.kr.
Kwangwoon University · KRKorea University · KRRajiv Gandhi Technical University · INYonsei University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Most cancer cells have telomerase activity because they can express the human telomerase reverse transcriptase (hTERT) gene. Therefore, the inhibition of the hTERT expression can play an important role in controlling cancer cell proliferation. Our current study aims to inhibit hTERT expression. For this, we synthesized graphene oxide (GO) and a functionalized multiwall carbon nanotube (f-MWCNT), latter treated them with cold atmospheric pressure plasma for further analysis of the hTERT expression. The inhibition of hTERT expression by GO, f-MWCNT, plasma activated GO solution (PGOS), and plasma activated f-MWCNT solution (PCNTS), was studied using two lung cancer cell lines, A549 and H460. The hTERT experimental results revealed that GO and PGOS sufficiently decreased the hTERT concentration, while f-MWCNT and PCNTS were unable to inhibit the hTERT concentration. Therefore, to understand the inhibition mechanism of hTERT, we studied the binding properties of GO and PGOS with telomere binding protein (AtTRB2). The interaction studies were carried out using circular dichroism, fluorescence,

Indexed as

Cell Line, TumorGraphiteHumansMolecular Docking SimulationNanostructuresNanotubes, CarbonPlasmaProtein ConformationTelomeraseTelomere-Binding Proteinsgraphene oxideGraphiteNanotubes, CarbonTelomeraseTelomere-Binding ProteinsTERT protein, human

Identifiers

PMID28572671
PMCPMC5454022
OpenAlexW2618108444

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.