ArticleScientific reports2017
Discovery of a polystyrene binding peptide isolated from phage display library and its application in peptide immobilization.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Multifunctional Nanobody Fusion Proteins in Immunoassays: Diverse Strategies for Enhanced Analytical Performance.Trends in analytical chemistry : TRAC · 2025Article
- LCI Engineering for Improved Polystyrene Binding: The Impact of Aromatic Amino Acid Substitutions.ACS omega · 2025Article
- Engineered Nanobodies for early and accurate diagnosis of dengue virus infection.PLoS neglected tropical diseases · 2025Article
- Discovery of Landscape Phage Probes Against Cellular Communication Network Factor 1 (CCN1/Cyr61).Viruses · 2025Article
- Microfluidic assessment of adhesion by surface display (MAPS-D): a novel method for evaluating peptide adhesion to polystyrene and poly(methyl methacrylate).RSC advances · 2025Article
- Development of an Anchor Bispecific Nanoantibody to Improve the Efficiency of Antigen Immobilization and Detection in a Well of a Polystyrene Plate.Doklady. Biochemistry and biophysics · 2025Article
- Simple, sensitive and specific detection method for polystyrene nanoplastics in food matrix based on peptide-modified FeCurrent research in food science · 2025Article
- Integrating biophysical modeling, quantum computing, and AI to discover plastic-binding peptides that combat microplastic pollution.PNAS nexus · 2025Article
- Production of high-affinity glycosylated anti-mouse conjugated nanobodies inFrontiers in bioengineering and biotechnology · 2025Article
- On the origin of non-specific binders isolated in the selection of phage display peptide libraries.Frontiers in microbiology · 2025Review
- Plastic Analysis with a Plasmonic Nano-Gold Sensor Coated with Plastic-Binding Peptides.Journal of xenobiotics · 2024Article
- Modular Design for Proteins Assembling into Antifouling Coatings: Case of Gold Surfaces.Langmuir : the ACS journal of surfaces and colloids · 2023Article
- The Use of Peptides in Veterinary Serodiagnosis of Infectious Diseases: A Review.Veterinary sciences · 2022Review
- The emerging role of selenium metabolic pathways in cancer: New therapeutic targets for cancer.Journal of cellular biochemistry · 2022Review
- Bioengineered textiles with peptide binders that capture SARS-CoV-2 viral particles.Communications materials · 2022Article
- Isolation of Cowpea Mosaic Virus-Binding Peptides.Biomacromolecules · 2021Article
- Preparation and Characterization of Anti-GPC3 Nanobody Against Hepatocellular Carcinoma.International journal of nanomedicine · 2020Article
- Assessment on interactive prospectives of nanoplastics with plasma proteins and the toxicological impacts of virgin, coronated and environmentally released-nanoplastics.Scientific reports · 2019Article
- Identification of a peptide for folate receptor alpha by phage display and its tumor targeting activity in ovary cancer xenograft.Scientific reports · 2018Article
- PSBinder: A Web Service for Predicting Polystyrene Surface-Binding Peptides.BioMed research international · 2017Article
Corrections and comments
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Authors and funding
11 authors.
Funding
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Abstract
Phage peptide display is a powerful technique for discovery of various target-specific ligands. However, target-unrelated peptides can often be obtained and cause ambiguous results. Peptide PB-TUP has been isolated repeatedly in our laboratory on different targets and we conducted a research on PB-TUP phage to investigate their binding properties and rate of propagation. ELISA and phage recovery assay demonstrated that PB-TUP phage had a significant superior affinity to polystyrene solid surface compared with control phage clones. In this study, some incidental bindings are excluded like blocking agents and non-specific binding of secondary antibodies. Propagation rate assays of the selected phage clones showed that the growth rate of PB-TUP phage was not superior to the control phages. Furthermore, the binding of PB-TUB to polystyrene was concentration dependent and varied with solution pH. Molecular modeling revealed that stable structures of α-helix and β-turn may contribute to the binding of PB-TUP to polystyrene plate. The PB-TUP sequence was fused to the N-terminus of peptide P2 and the fusion peptide significantly increased the binding affinity to polystyrene. The fusion peptide also enhanced the cell adhesion ability of peptide P2 with human umbilical vein endothelial cell (HUVEC). The addition of the polystyrene binding peptide provided a convenient method for peptide immobilization.
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