ArticleScientific reports2017
Cognitive ability and physical health: a Mendelian randomization study.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.Nature neuroscience · 2019Pooled it
- Can increasing years of schooling reduce type 2 diabetes (T2D)?: Evidence from a Mendelian randomization of T2D and 10 of its risk factors.Scientific reports · 2020Trial
- Disentangling the relationship between glucose, insulin and brain health: A UK Biobank study.Diabetes, obesity & metabolism · 2026Article
- Lifestyle Modify Optic Nerve Injury in Mendelian Randomization.Genetics research · 2025Article
- Optimizing athletic engagement and performance of obese students: an adaptive approach through basketball in physical education.Frontiers in sports and active living · 2024Article
- Adherence to dietary recommendations by socioeconomic status in the United Kingdom biobank cohort study.Frontiers in nutrition · 2024Article
- The relationship between adiposity and cognitive function: a bidirectional Mendelian randomization study in UK Biobank.International journal of epidemiology · 2023Article
- Genetic analyses identify brain structures related to cognitive impairment associated with elevated blood pressure.European heart journal · 2023Observational
- Adiposity impacts cognitive function in Asian populations: an epidemiological and Mendelian Randomization study.The Lancet regional health. Western Pacific · 2023Article
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- The effects of adapted physical education sessions on the empathy of female students with overweight.Frontiers in psychology · 2023Article
- The association between a lifestyle score, socioeconomic status, and COVID-19 outcomes within the UK Biobank cohort.BMC infectious diseases · 2022Article
- Impact of polygenic risk for coronary artery disease and cardiovascular medication burden on cognitive impairment in psychotic disorders.Progress in neuro-psychopharmacology & biological psychiatry · 2022Article
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- Dementia risk reduction: why haven't the pharmacological risk reduction trials worked? An in-depth exploration of seven established risk factors.Alzheimer's & dementia (New York, N. Y.) · 2021Review
- Association of blood pressure with cognitive function at midlife: a Mendelian randomization study.BMC medical genomics · 2020Article
- Empirical comparisons of multiple Mendelian randomization approaches in the presence of assortative mating.International journal of epidemiology · 2020Article
- Ethnic and socioeconomic differences in SARS-CoV-2 infection: prospective cohort study using UK Biobank.BMC medicine · 2020Article
- Neurocognitive impairment in type 2 diabetes: evidence for shared genetic aetiology.Diabetologia · 2020Article
- The association of clinical phenotypes to known AD/FTD genetic risk loci and their inter-relationship.PloS one · 2020Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Causes of the association between cognitive ability and health remain unknown, but may reflect a shared genetic aetiology. This study examines the causal genetic associations between cognitive ability and physical health. We carried out two-sample Mendelian randomization analyses using the inverse-variance weighted method to test for causality between later life cognitive ability, educational attainment (as a proxy for cognitive ability in youth), BMI, height, systolic blood pressure, coronary artery disease, and type 2 diabetes using data from six independent GWAS consortia and the UK Biobank sample (N = 112 151). BMI, systolic blood pressure, coronary artery disease and type 2 diabetes showed negative associations with cognitive ability; height was positively associated with cognitive ability. The analyses provided no evidence for casual associations from health to cognitive ability. In the other direction, higher educational attainment predicted lower BMI, systolic blood pressure, coronary artery disease, type 2 diabetes, and taller stature. The analyses indicated no causal association from educational attainment to physical health. The lack of evidence for causal associations between cognitive ability, educational attainment, and physical health could be explained by weak instrumental variables, poorly measured outcomes, or the small number of disease cases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.