ArticleScientific reports2017
Label-Free Fluorescence Spectroscopy for Detecting Key Biomolecules in Brain Tissue from a Mouse Model of Alzheimer's Disease.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 51 citations in OpenAlex.
- Cell-MICS: Detecting Immune Cells With Label-Free Two-Photon Autofluorescence and Deep Learning.Journal of biophotonics · 2026Article
- Metabolic light absorption, scattering, and emission (MetaLASE) microscopy.Science advances · 2024Article
- Multispectral Imaging of Metabolic Fluorophores: Comparing In Vivo and Fresh Ex Vivo Tissue.Critical reviews in eukaryotic gene expression · 2024Article
- Two-Photon Imaging for Non-Invasive Corneal Examination.Sensors (Basel, Switzerland) · 2022Review
- Unlocking autofluorescence in the era of full spectrum analysis: Implications for immunophenotype discovery projects.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2022Article
- Alzheimer's disease diagnosis by blood plasma molecular fluorescence spectroscopy (EEM).Scientific reports · 2022Article
- Fluorescence Anisotropy Sensor Comprising a Dual Hollow-Core Antiresonant Fiber Polarization Beam Splitter.Sensors (Basel, Switzerland) · 2020Article
- Real-time detection of breast cancer at the cellular level.Journal of cellular physiology · 2019Review
- Development of a low-cost and portable smart fluorometer for detecting breast cancer cells.Biomedical optics express · 2019Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
In this study, label-free fluorescence spectroscopy was used for the first time to determine spectral profiles of tryptophan, reduced nicotinamide adenine dinucleotide (NADH), and flavin denine dinucleotide (FAD) in fresh brain samples of a mouse model of Alzheimer's disease (AD). Our results showed that the emission spectral profile levels of tryptophan and NADH were higher in AD samples than normal samples. The intensity ratio of tryptophan to NADH and the change rate of fluorescence intensity with respect to wavelength also increased in AD brain. These results yield an optical method for detecting early stage of AD by comparing spectral profiles of biomolecules.
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Registered trials
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