ArticleScientific reports2017
Three-Dimensional Geometry of Collagenous Tissues by Second Harmonic Polarimetry.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Collagen Mechanics.Sub-cellular biochemistry · 2026Review
- Mueller matrix polarimetry for quantitative evaluation of the Achilles tendon injury recovery.Frontiers of optoelectronics · 2024Article
- Polarimetric second-harmonic generation microscopy of partially oriented fibers I: Digital modeling.Biophysical journal · 2023Article
- Polarimetric second harmonic generation microscopy of partially oriented fibers II: Imaging study.Biophysical journal · 2023Article
- Polarimetric imaging microscopy for advanced inspection of vegetal tissues.Scientific reports · 2021Article
- Three-dimensional characterization of collagen remodeling in cell-seeded collagen scaffolds via polarization second harmonic generation.Biomedical optics express · 2021Article
- Spatial frequency metrics for analysis of microscopic images of musculoskeletal tissues.Connective tissue research · 2021Article
- Quantification of collagen fiber structure using second harmonic generation imaging and two-dimensional discrete Fourier transform analysis: Application to the human optic nerve head.Journal of biophotonics · 2019Article
- Whole-Section Tumor Micro-Architecture Analysis by a Two-Dimensional Phasor-Based Approach Applied to Polarization-Dependent Second Harmonic Imaging.Frontiers in oncology · 2019Article
- Challenges and opportunities in clinical translation of biomedical optical spectroscopy and imaging.Journal of biomedical optics · 2018Review
- Hyperspectral imaging with laser-scanning sum-frequency generation microscopy.Biomedical optics express · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Collagen is a biological macromolecule capable of second harmonic generation, allowing label-free detection in tissues; in addition, molecular orientation can be determined from the polarization dependence of the second harmonic signal. Previously we reported that in-plane orientation of collagen fibrils could be determined by modulating the polarization angle of the laser during scanning. We have now extended this method so that out-of-plane orientation angles can be determined at the same time, allowing visualization of the 3-dimensional structure of collagenous tissues. This approach offers advantages compared with other methods for determining out-of-plane orientation. First, the orientation angles are directly calculated from the polarimetry data obtained in a single scan, while other reported methods require data from multiple scans, use of iterative optimization methods, application of fitting algorithms, or extensive post-optical processing. Second, our method does not require highly specialized instrumentation, and thus can be adapted for use in almost any nonlinear optical microscopy setup. It is suitable for both basic and clinical applications. We present three-dimensional images of structurally complex collagenous tissues that illustrate the power of such 3-dimensional analyses to reveal the architecture of biological structures.
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Registered trials
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