Evidence map›Paper›PMID 28572495›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2017

Comparison of the vasodilatory effects of sodium nitroprusside vs. nitroglycerin.

Sushant M Ranadive, Andy R Eugene, Gabrielle Dillon, Wayne T Nicholson, Michael J Joyner

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. In utero exposure to alcohol alters reactivity of cerebral arterioles.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019
    Article
  10. Management of hypertensive crises in the elderly.Journal of geriatric cardiology : JGC · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sushant M RanadiveDepartment of Anesthesiology, Mayo Clinic, Rochester, Minnesota Ranadive.Sushant@Mayo.edu.
Andy R EugeneDepartment of Anesthesiology, Mayo Clinic, Rochester, Minnesota.
Gabrielle DillonDepartment of Anesthesiology, Mayo Clinic, Rochester, Minnesota.
Wayne T NicholsonDepartment of Anesthesiology, Mayo Clinic, Rochester, Minnesota.
Michael J JoynerDepartment of Anesthesiology, Mayo Clinic, Rochester, Minnesota.
Mayo Clinic · US

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
TRAINING GRANT IN CLINICAL PHARMACOLOGYT32GM008685 · NIGMS · MAYO CLINIC ROCHESTER · PI Liewei Wang · 1998 to 2026
$8.2M
Mayo Clinic Interdisciplinary Women's Health Research ProgramK12HD065987 · NICHD · MAYO CLINIC ROCHESTER · PI KANTARCI, KEJAL · 2010 to 2023
$6.7M
Exercise Hyperemia in HumansR01HL119337 · NHLBI · MAYO CLINIC ROCHESTER · PI DINENNO, FRANK A, JOYNER, MICHAEL J · 2014 to 2017
$3.0M
NCATS NIH HHS UL1 TR000135NHLBI NIH HHS R01 HL119337NICHD NIH HHS K12 HD065987NIGMS NIH HHS T32 GM008685
6 · The paper itself

Abstract

The vasodilatory mechanism of Nntroglycerin (NTG) is similar to sodium nitroprusside (SNP) in regard to action on guanosine 3'5'-monophosphate (cyclic GMP) via nitric oxide. However, it is unknown whether NTG can achieve the same magnitude of vasodilation in the forearm as SNP. Therefore, the purpose of the study was to evaluate the differences in forearm blood flow (FBF) and forearm vascular conductance (FVC) during escalating infusions of NTG vs. SNP at similar concentration doses and rates. We measured FBF using venous occlusion plethysmography (VOP) and Doppler ultrasound in eight young, healthy participants (mean age = 28 ± 2 yr) during four forearm volume (FAV)-specific doses (0.25, 0.5, 1, and 2 µg·100 ml FAV

Indexed as

AdultBrachial ArteryEndothelium, VascularFemaleForearmHumansMaleNitric OxideNitroglycerinNitroprussidePlethysmographyRegional Blood FlowVascular ResistanceVasodilationVasodilator AgentsNitric OxideNitroglycerinNitroprussideVasodilator AgentsDoppler ultrasoundvasodilatorsvenous occlusion plethysmography

Identifiers

PMID28572495
PMCPMC5583612
OpenAlexW2621104675

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.