Evidence map›Paper›PMID 28572446›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2017

Histone deacetylase 1 activates PU.1 gene transcription through regulating TAF9 deacetylation and transcription factor IID assembly.

Wei Jian, Bowen Yan, Suming Huang, Yi Qiu

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Activation of TAF9Frontiers in pharmacology · 2021
    Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Wei JianDepartment of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, Florida, USA.
Bowen YanDepartment of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, Florida, USA.
Suming HuangDepartment of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, Florida, USA; and.
Yi QiuDepartment of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, Florida, USA; qiuy@ufl.edu.
Florida College · USMacau University of Science and Technology · MOUniversity of Florida · US

Funding

The role of HDAC1 acetylation on corepressor complex activity and hematopoiesisR01HL095674 · NHLBI · UNIVERSITY OF FLORIDA · PI QIU, YI · 2010 to 2013
$1.4M
The Role of Long Noncoding RNA in HematopoiesisR01DK110108 · NIDDK · UNIVERSITY OF FLORIDA · PI HUANG, SUMING · 2016 to 2019
$1.3M
NHLBI NIH HHS R01 HL095674NIDDK NIH HHS R01 DK110108
6 · The paper itself

Abstract

Histone acetyltransferases and histone deacetylases (HDACs) are important epigenetic coregulators. It has been thought that HDACs associate with corepressor complexes and repress gene transcription; however, in this study, we have found that PU.1-a key master regulator for hematopoietic self-renewal and lineage specification-requires HDAC activity for gene activation. Deregulated PU.1 gene expression is linked to dysregulated hematopoiesis and the development of leukemia. In this study, we used erythroid differentiation as a model to analyze how the PU.1 gene is regulated. We found that active HDAC1 is directly recruited to active PU.1 promoter in progenitor cells, whereas acetylated HDAC1, which is inactive, is on the silenced PU.1 promoter in differentiated erythroid cells. We then studied the mechanism of HDAC1-mediated activation. We discovered that HDAC1 activates PU.1 gene transcription

Indexed as

AnimalsErythroid CellsErythropoiesisHistone Deacetylase 1HumansK562 CellsMiceProtein BindingProto-Oncogene ProteinsProto-Oncogene Protein Spi-1RAW 264.7 CellsTATA-Binding Protein Associated FactorsT-LymphocytesTrans-ActivatorsTranscription Factor TFIIDHistone Deacetylase 1Proto-Oncogene ProteinsProto-Oncogene Protein Spi-1TAF9 protein, humanTATA-Binding Protein Associated FactorsTrans-ActivatorsTranscription Factor TFIIDacetylationdownstream promoter elementHDAC1HDACiTFIID

Identifiers

PMID28572446
PMCPMC5572695
OpenAlexW2621247544

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.