ArticleHaematologica2017
Risk of cardiovascular events and pulmonary hypertension following splenectomy - a Danish population-based cohort study from 1996-2012.
Article in Haematologica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Where would immune thrombocytopenia be without intravenous gammaglobulin?Haematologica · 2026Article
- Arterial Thrombosis in Patients with Primary Immune Thrombocytopenia: A Nationwide StudyTurkish journal of haematology : official journal of Turkish Society of Haematology · 2025Article
- Cerebrovascular involvement in hereditary spherocytosis: observational cohort and case-control MRI study.Orphanet journal of rare diseases · 2025Observational
- Is splenectomy one of the contributory factors to pulmonary hypertension? An analysis of splenectomized hemolytic anemia and immune thrombocytopenia patients.Annals of hematology · 2025Article
- The spleen in ischaemic heart disease.Nature reviews. Cardiology · 2025Review
- Underlying disease is the main risk factor in post-splenectomy complication risk: Data from a national database.British journal of haematology · 2025Article
- Cost-effectiveness of second-line therapies in adults with chronic immune thrombocytopenia.American journal of hematology · 2023Article
- Review
- Emerging Therapies in Immune Thrombocytopenia.Journal of clinical medicine · 2021Review
- Assessment of thrombotic risk during long-term treatment of immune thrombocytopenia with fostamatinib.Therapeutic advances in hematology · 2021Article
- Immune Thrombocytopenia: Are We Stuck in the Mud or Is There Light at the End of the Tunnel?Clinical hematology international · 2019Article
- The non-coding RNome after splenectomy.Journal of cellular and molecular medicine · 2019Article
- Article
- Inflammatory Macrophage Expansion in Pulmonary Hypertension Depends upon Mobilization of Blood-Borne Monocytes.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Article
- Review
- Recent advances in understanding and management of acquired thrombocytopenia.F1000Research · 2018Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Splenectomized patients are at increased risk of cardiovascular events, but it remains unclear whether this is due to lack of the spleen or due to the underlying disease leading to splenectomy. We aimed to assess the risk of myocardial infarction, pulmonary hypertension, and stroke following splenectomy. We identified patients splenectomized in Denmark between 1996 and 2012. We constructed two comparison cohorts: an age- and sex-matched general population cohort and a disease-matched cohort based on the splenectomy-related underlying disease. We computed 5-year cumulative incidences and adjusted hazard ratios of myocardial infarction, pulmonary hypertension, and stroke for the three cohorts. The study included 5,306 splenectomized patients, 53,060 members of the general population, and 11,651 disease-matched patients. During the 5-year follow-up, 1.3% of splenectomized patients had a myocardial infarction
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