Evidence map›Paper›PMID 28572086›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2017

Functional morphology of the lower esophageal sphincter and crural diaphragm determined by three-dimensional high-resolution esophago-gastric junction pressure profile and CT imaging.

Ravinder K Mittal, Ali Zifan, Dushyant Kumar, Melissa Ledgerwood-Lee, Erika Ruppert, Gary Ghahremani

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Demographic and Manometric Variables Can Independently Predict Gastroesophageal Reflux Disease: The AGES-D Score.The Korean journal of helicobacter and upper gastrointestinal research · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Endoscopic Management of GERD.Digestive diseases and sciences · 2022
    Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Observational
  15. Tissue engineering of the gastroesophageal junction.Journal of tissue engineering and regenerative medicine · 2020
    Review
  16. Article
  17. Article
  18. Botox injection into the lower esophageal sphincter induces hiatal paralysis and gastroesophageal reflux.American journal of physiology. Gastrointestinal and liver physiology · 2020
    Article
  19. Surgical Anatomy of Paraesophageal Hernias.Thoracic surgery clinics · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ravinder K MittalDepartment of Medicine, University of California, San Diego, California; and rmittal@ucsd.edu.
Ali ZifanDepartment of Medicine, University of California, San Diego, California; and.
Dushyant KumarDepartment of Medicine, University of California, San Diego, California; and.
Melissa Ledgerwood-LeeDepartment of Medicine, University of California, San Diego, California; and.
Erika RuppertDepartment of Medicine, University of California, San Diego, California; and.
Gary GhahremaniDepartment of Medicine, University of California, San Diego, California; and.
University of California, San Diego · US

Funding

Genesis of Esophageal Pain: Longitudinal Muscle Spasm and Wall IschemiaR01DK060733 · NIDDK · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI MITTAL, RAVINDER K. · 2002 to 2016
$3.9M
Novel Electrical Impedance Methodology to Understand Functional DysphagiaR01DK109376 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MITTAL, RAVINDER K. · 2016 to 2020
$2.5M
NIDDK NIH HHS R01 DK060733NIDDK NIH HHS R01 DK109376
6 · The paper itself

Abstract

The smooth muscles of the lower esophageal sphincter (LES) and skeletal muscles of the crural diaphragm (CD) provide a closure/antireflux barrier mechanism at the esophago-gastric junction (EGJ). A number of questions in regard to the pressure profile of the LES and CD remain unclear, e.g.,

Indexed as

AdultDiaphragmEsophageal Sphincter, LowerFemaleHumansMaleMiddle AgedTomography, X-Ray Computedcircumferential asymmetry of the LOS pressurecomputed tomographycrural diaphragm and LOS pressurefunctional morphology of the esophago-gastric junction

Identifiers

PMID28572086
PMCPMC5625133
OpenAlexW2621296478

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.