Evidence map›Paper›PMID 28572085›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2017

CDX2 upregulates SLC26A3 gene expression in intestinal epithelial cells.

Ishita Chatterjee, Anoop Kumar, Rosa María Castilla-Madrigal, Oscar Pellon-Cardenas, Ravinder K Gill, Waddah A Alrefai, Alip Borthakur, Michael Verzi, Pradeep K Dudeja

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. SLC26A3 (DRA) is stimulated in a synergistic, intracellular CaAmerican journal of physiology. Cell physiology · 2023
    Article
  4. In vivo evaluation of anticryptosporidial effects of wheat germ extracts in immunocompromised mice.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. SLC26A3 (DRA) prevents TNF-alpha-induced barrier dysfunction and dextran sulfate sodium-induced acute colitis.Laboratory investigation; a journal of technical methods and pathology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Ishita ChatterjeeDivision of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois.
Anoop KumarDivision of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois.
Rosa María Castilla-MadrigalDepartment of Nutrition, Food Science, and Physiology, University of Navarra, Pamplona, Spain; and.
Oscar Pellon-CardenasDepartment of Genetics, Rutgers University, Piscataway, New Jersey.
Ravinder K GillDivision of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois.
Waddah A AlrefaiJesse Brown Veterans Affairs Medical Center, Chicago, Illinois.
Alip BorthakurDivision of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois.ORCID http://orcid.org/0000-0002-5792-1279
Michael VerziDepartment of Genetics, Rutgers University, Piscataway, New Jersey.
Pradeep K DudejaJesse Brown Veterans Affairs Medical Center, Chicago, Illinois; pkdudeja@uic.edu.
University of Illinois Chicago · USRutgers, The State University of New Jersey · USUniversidad de Navarra · ES

Funding

Intestinal Anion Transporters: Function and RegulationR01DK054016 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DUDEJA, PRADEEP K · 1998 to 2022
$7.0M
TRANSPORT MECHANISMS IN THE SMALL INTESTINER01DK033349 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DUDEJA, PRADEEP K · 1986 to 2012
$3.8M
Transporter Trafficking Mechanisms in Infectious DiarrheaR01DK092441 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DUDEJA, PRADEEP K · 2011 to 2020
$3.0M
Intestinal 5-HT Transporter: A novel therapeutic target for GI disordersR01DK098170 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GILL, RAVINDER K · 2014 to 2022
$3.0M
Regulation of Intestinal Bile Acid TransportR01DK071596 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ALREFAI, WADDAH A. · 2005 to 2014
$2.3M
Gut-liver crosstalk in bile-acid induced diarrheaR01DK109709 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ALREFAI, WADDAH A. · 2016 to 2019
$1.1M
Modulation of NHE Activity by EPEC InfectionR01DK068324 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DUDEJA, PRADEEP K · 2004 to 2006
$648k
Mechanisms of Regulation of Intestinal Cl Absorption in IBD Associated DiarrheaI01BX002011 · VA · JESSE BROWN VA MEDICAL CENTER · PI DUDEJA, PRADEEP K · 2013 to 2024
–
BLRD VA I01 BX000152BLRD VA I01 BX002011BLRD VA IK6 BX005243NIDDK NIH HHS R01 DK033349NIDDK NIH HHS R01 DK054016NIDDK NIH HHS R01 DK068324NIDDK NIH HHS R01 DK071596NIDDK NIH HHS R01 DK092441NIDDK NIH HHS R01 DK098170NIDDK NIH HHS R01 DK109709
6 · The paper itself

Abstract

SLC26A3 [downregulated in adenoma (DRA)] plays a key role in mammalian intestinal NaCl absorption, in that it mediates apical membrane Cl

Indexed as

AnimalsAntiportersCaco-2 CellsCDX2 Transcription FactorChloride-Bicarbonate AntiportersGene Expression RegulationHumansMiceRNA InterferenceRNA, Small InterferingSulfate TransportersAntiportersCDX2 protein, humanCdx2 protein, mouseCDX2 Transcription FactorChloride-Bicarbonate AntiportersRNA, Small InterferingSLC26A3 protein, humanSlc26a3 protein, mouseSulfate TransportersCDX2SLC26A3transcription

Identifiers

PMID28572085
PMCPMC5625132
OpenAlexW2621256940

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.