Evidence map›Paper›PMID 28572001›Full record

ArticleAcademic radiology2017

Quantitative FLAIR MRI in Amyotrophic Lateral Sclerosis.

Jeremy Fabes, Lucy Matthews, Nicola Filippini, Kevin Talbot, Mark Jenkinson, Martin R Turner

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Academic radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Review
  7. Primary Lateral Sclerosis: An Overview.Journal of clinical medicine · 2024
    Review
  8. Review
  9. Amyotrophic lateral sclerosis.Lancet (London, England) · 2022
    Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Primary lateral sclerosis: consensus diagnostic criteria.Journal of neurology, neurosurgery, and psychiatry · 2020
    Article
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Jeremy FabesCentre for Functional Magnetic Resonance Imaging of the Brain, Oxford University, John Radcliffe Hospital, West Wing Level 6, Oxford OX3 9DU, UK.
Lucy MatthewsCentre for Functional Magnetic Resonance Imaging of the Brain, Oxford University, John Radcliffe Hospital, West Wing Level 6, Oxford OX3 9DU, UK; Nuffield Department of Clinical Neurosciences, Oxford University, John Radcliffe Hospital, West Wing Level 6, Oxford OX3 9DU, UK.
Nicola FilippiniCentre for Functional Magnetic Resonance Imaging of the Brain, Oxford University, John Radcliffe Hospital, West Wing Level 6, Oxford OX3 9DU, UK; Department of Psychiatry, Oxford University, John Radcliffe Hospital, Oxford, UK; Oxford University Centre for Magnetic Resonance Research, John Radcliffe Hospital, West Wing Level 6, Oxford OX3 9DU, UK.
Kevin TalbotNuffield Department of Clinical Neurosciences, Oxford University, John Radcliffe Hospital, West Wing Level 6, Oxford OX3 9DU, UK.
Mark JenkinsonCentre for Functional Magnetic Resonance Imaging of the Brain, Oxford University, John Radcliffe Hospital, West Wing Level 6, Oxford OX3 9DU, UK.
Martin R TurnerCentre for Functional Magnetic Resonance Imaging of the Brain, Oxford University, John Radcliffe Hospital, West Wing Level 6, Oxford OX3 9DU, UK; Nuffield Department of Clinical Neurosciences, Oxford University, John Radcliffe Hospital, West Wing Level 6, Oxford OX3 9DU, UK; Oxford University Centre for Magnetic Resonance Research, John Radcliffe Hospital, West Wing Level 6, Oxford OX3 9DU, UK. Electronic address: martin.turner@ndcn.ox.ac.uk.

Funding

Medical Research Council MR/K01014X/1Motor Neurone Disease Association TURNER/JAN13/944-795
6 · The paper itself

Abstract

RATIONALE AND

objectivesT2-weighted magnetic resonance imaging (MRI) hyperintensity assessed visually in the corticospinal tract (CST) lacks sensitivity for a diagnosis of amyotrophic lateral sclerosis (ALS). We sought to explore a quantitative approach to fluid-attenuated inversion recovery (FLAIR) MRI intensity across a range of ALS phenotypes. MATERIALS AND

methodsThirty-three classical ALS patients, 10 with a flail arm presentation, and six with primary lateral sclerosis underwent MRI at 3 Tesla. Comparisons of quantitative FLAIR intensity in the CST and corpus callosum were made between 21 healthy controls and within patient phenotypic subgroups, some of whom were studied longitudinally.

resultsMean FLAIR intensity was greater in patient groups. The cerebral peduncle intensity provided the strongest subgroup classification. FLAIR intensity increased longitudinally. The rate of change of FLAIR within CST correlated with rate of decline in executive function and ALS functional rating score.

conclusionsFLAIR MRI encodes quantifiable information of potential diagnostic, stratification, and monitoring value.

Indexed as

AdultAgedAmyotrophic Lateral SclerosisCorpus CallosumExecutive FunctionFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle AgedPyramidal TractsAmyotrophic lateral sclerosisbiomarkermotor neuron diseaseneuroimagingphenotypeprognosis

Identifiers

PMID28572001
PMCPMC5605225

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.