ArticleJournal of diabetes and its complications2017
Dissociation of local and global skeletal muscle oxygen transport metrics in type 2 diabetes.
Article in Journal of diabetes and its complications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Exercise Intolerance in Type 2 Diabetes: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2025Pooled it
- Sitagliptin improves diastolic cardiac function but not cardiorespiratory fitness in adults with type 2 diabetes.Journal of diabetes and its complications · 2019Trial
- Supplemental Oxygen Improves In Vivo Mitochondrial Oxidative Phosphorylation Flux in Sedentary Obese Adults With Type 2 Diabetes.Diabetes · 2018Trial
- Article
- Skeletal muscle microvascular hemodynamic responses during hyperinsulinemic-euglycemic clamp in a Zucker Diabetic Sprague Dawley rat model of type 2 diabetes.Frontiers in physiology · 2025Article
- Peripheral tissue perfusion in individuals with and without type 2 diabetes mellitus and its associations with type 2 diabetes: a cross-sectional study.Jornal vascular brasileiro · 2025Article
- Association Between Microvascular Disease and Cardiorespiratory Fitness Among Adults With Type 2 Diabetes.Diabetes care · 2024Article
- Differences in peripheral microcirculatory blood flow regulation in chronic kidney disease based on wavelet analysis of resting near-infrared spectroscopy.Microvascular research · 2024Article
- The role of the microcirculation and integrative cardiovascular physiology in the pathogenesis of ICU-acquired weakness.Frontiers in physiology · 2023Review
- Glucose Uptake by Skeletal Muscle within the Contexts of Type 2 Diabetes and Exercise: An Integrated Approach.Nutrients · 2022Review
- Single-leg exercise training augments in vivo skeletal muscle oxidative flux and vascular content and function in adults with type 2 diabetes.The Journal of physiology · 2022Article
- Monitoring adaptation of skin tissue oxygenation during cycling ergometer exercise by frequency-domain diffuse optical spectroscopy.Biomedical optics express · 2021Article
- Mechanistic Causes of Reduced Cardiorespiratory Fitness in Type 2 Diabetes.Journal of the Endocrine Society · 2020Review
- GLP-1 and insulin regulation of skeletal and cardiac muscle microvascular perfusion in type 2 diabetes.Journal of diabetes · 2020Review
- Near-infrared Spectroscopy of Vastus Lateralis Muscle during Incremental Cycling Exercise in patients with Type 2 Diabetes.Physical therapy research · 2020Article
- Automated quantification of microvascular perfusion.Microcirculation (New York, N.Y. : 1994) · 2018Article
- Acute vitamin C improves cardiac function, not exercise capacity, in adults with type 2 diabetes.Diabetology & metabolic syndrome · 2018Article
- Mechanisms of Aerobic Exercise Impairment in Diabetes: A Narrative Review.Frontiers in endocrinology · 2018Review
- Myopenia and precision (P4) medicine.Journal of cachexia, sarcopenia and muscle · 2017Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
aimsExercise capacity is impaired in type 2 diabetes, and this impairment predicts excess morbidity and mortality. This defect appears to involve excess skeletal muscle deoxygenation, but the underlying mechanisms remain unclear. We hypothesized that reduced blood flow, reduced local recruitment of blood volume/hematocrit, or both contribute to excess skeletal muscle deoxygenation in type 2 diabetes.
methodsIn patients with (n=23) and without (n=18) type 2 diabetes, we recorded maximal reactive hyperemic leg blood flow, peak oxygen utilization during cycling ergometer exercise (VO
resultsWe observed a significant increase (p<0.05) in skeletal muscle deoxygenation in type 2 diabetes despite similar blood flow and recruitment of local blood volume/hematocrit. Within the control group skeletal muscle deoxygenation, local recruitment of microvascular blood volume/hematocrit, blood flow, and VO
conclusionsThese results suggest that in type 2 diabetes 1) skeletal muscle oxygenation is impaired, 2) this impairment may occur independently of bulk blood flow or local recruitment of blood volume/hematocrit, and 3) local and global metrics of oxygen transport are dissociated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.