ArticleNanomedicine : nanotechnology, biology, and medicine2018
Self-powered therapeutic release from conducting polymer/graphene oxide films on magnesium.
Article in Nanomedicine : nanotechnology, biology, and medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Improving the Biocompatibility and Functionality of Neural Interface Devices with Silica Nanoparticles.Accounts of chemical research · 2024Article
- Electrically Controlled Vasodilator Delivery from PEDOT/Silica Nanoparticle Modulates Vessel Diameter in Mouse Brain.Advanced healthcare materials · 2024Article
- Advances in Multifunctional Bioactive Coatings for Metallic Bone Implants.Materials (Basel, Switzerland) · 2022Review
- Article
- The advances in nanomedicine for bone and cartilage repair.Journal of nanobiotechnology · 2022Review
- Recent advances in the aqueous applications of PEDOT.Nanoscale advances · 2022Review
- Graphene for Antimicrobial and Coating Application.International journal of molecular sciences · 2022Review
- Electrically Conducting Hydrogels for Health care: Concept, Fabrication Methods, and Applications.International journal of bioprinting · 2020Review
- Nanoparticle Doped PEDOT for Enhanced Electrode Coatings and Drug Delivery.Advanced healthcare materials · 2019Article
- Meningeal inflammatory response and fibrous tissue remodeling around intracortical implants: An in vivo two-photon imaging study.Biomaterials · 2019Article
- Conducting Polymers, Hydrogels and Their Composites: Preparation, Properties and Bioapplications.Polymers · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Magnesium's complete in vivo degradation is appealing for medical implant applications. Rapid corrosion and hydrogen bubble generation along with inflammatory host tissue response have limited its clinical use. Here we electropolymerized a poly (3,4-ethylenedioxythiophene) (PEDOT) and graphene oxide (GO) film directly on Mg surface. GO acted as nano-drug carrier to carry anti-inflammatory drug dexamethasone (Dex). PEDOT/GO/Dex coatings improved Mg corrosion resistance and decreased the rate of hydrogen production. Dex could be released driven by the electrical current generated from Mg corrosion. The anti-inflammatory activity of the released Dex was confirmed in microglia cultures. This PEDOT/GO/Dex film displayed the ability to both control Mg corrosion and act as an on demand release coating that delivers Dex at the corrosion site to minimize detrimental effects of corrosion byproducts. Such multi-functional smart coating will improve the clinical use of Mg implants. Furthermore, the PEDOT/GO/Drug/Mg system may be developed into self-powered implantable drug delivery devices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.