Evidence map›Paper›PMID 28571652›Full record

ArticleNeurobiology of aging2017

Functional neuroanatomy of speech signal decoding in primary progressive aphasias.

Chris J D Hardy, Jennifer L Agustus, Charles R Marshall, Camilla N Clark, Lucy L Russell, Emilie V Brotherhood, Rebecca L Bond, Cassidy M Fiford, Sasha Ondobaka, David L Thomas and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Non-verbal dichotic listening: A new cognitive hearing test for dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Speech perception and language comprehension in primary progressive aphasia.Cortex; a journal devoted to the study of the nervous system and behavior · 2024
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Symptom-led staging for primary progressive aphasia.medRxiv : the preprint server for health sciences · 2023
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Laughter as a paradigm of socio-emotional signal processing in dementia.Cortex; a journal devoted to the study of the nervous system and behavior · 2021
    Article
  18. Review
  19. Hearing and dementia: from ears to brain.Brain : a journal of neurology · 2021
    Review
  20. Primary Progressive Aphasia: Toward a Pathophysiological Synthesis.Current neurology and neuroscience reports · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Chris J D HardyDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.
Jennifer L AgustusDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.
Charles R MarshallDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.
Camilla N ClarkDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.
Lucy L RussellDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.
Emilie V BrotherhoodDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.
Rebecca L BondDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.
Cassidy M FifordDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.
Sasha OndobakaWellcome Centre for Neuroimaging, UCL Institute of Neurology, University College London, London, UK.
David L ThomasDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK; Leonard Wolfson Experimental Neurology Centre, UCL Institute of Neurology, University College London, London, UK.
Sebastian J CrutchDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.
Jonathan D RohrerDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.
Jason D WarrenDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK. Electronic address: jason.warren@ucl.ac.uk.
UK Dementia Research Institute · GBUniversity College London · GBWellcome Centre for Human Neuroimaging · GB

Funding

Medical Research Council MR/J009482/1Medical Research Council MR/M008525/1Medical Research Council MR/M009106/1Medical Research Council MR/M023664/1Wellcome TrustWellcome Trust 091673/Z/10/Z
6 · The paper itself

Abstract

The pathophysiology of primary progressive aphasias remains poorly understood. Here, we addressed this issue using activation fMRI in a cohort of 27 patients with primary progressive aphasia (nonfluent, semantic, and logopenic variants) versus 15 healthy controls. Participants listened passively to sequences of spoken syllables in which we manipulated 3-key auditory speech signal characteristics: temporal regularity, phonemic spectral structure, and pitch sequence entropy. Relative to healthy controls, nonfluent variant patients showed reduced activation of medial Heschl's gyrus in response to any auditory stimulation and reduced activation of anterior cingulate to temporal irregularity. Semantic variant patients had relatively reduced activation of caudate and anterior cingulate in response to increased entropy. Logopenic variant patients showed reduced activation of posterior superior temporal cortex to phonemic spectral structure. Taken together, our findings suggest that impaired processing of core speech signal attributes may drive particular progressive aphasia syndromes and could index a generic physiological mechanism of reduced computational efficiency relevant to all these syndromes, with implications for development of new biomarkers and therapeutic interventions.

Indexed as

Acoustic StimulationAgedAphasia, Primary ProgressiveCohort StudiesFemaleFrontotemporal DementiaHumansMagnetic Resonance ImagingMaleMiddle AgedSemanticsSpeechTemporal LobeFrontotemporal dementiaFunctional magnetic resonance imagingLogopenic aphasiaPrimary progressive aphasiaProgressive nonfluent aphasiaSemantic dementia

Identifiers

PMID28571652
PMCPMC5476347
OpenAlexW2612092148

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.