ArticleJournal of the American College of Cardiology2017
Longitudinal Outcomes of Patients With Single Ventricle After the Fontan Procedure.
Article in Journal of the American College of Cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00132782 (Relationship Between Functional Health Status and Ventricular Performance After Fontan), which is not on this map. Cited by 115 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Relationship Between Functional Health Status and Ventricular Performance After Fontan (A Trial Conducted by the Pediatric Heart Network)
Who cites it
115 citing papers in PubMed, 3 syntheses or guidelines pooled it, 275 citations in OpenAlex.
- Outcomes for congenitally corrected transposition of great arteries using various surgical techniques: a systematic review and network meta-analysis.Annals of the Royal College of Surgeons of England · 2026Pooled it
- Fontan Patients with a Systemic Left Ventricle Have Greater Exercise Capacity than those with a Systemic Right Ventricle: A Systematic Review and Meta-Analysis.Pediatric cardiology · 2026Pooled it
- Health-Related Quality of Life in Children, Adolescents, and Adults With a Fontan Circulation: A Meta-Analysis.Journal of the American Heart Association · 2020Pooled it
- Systolic performance of the single ventricle, exercise capacity, and endothelial function in pediatric Fontan patients.American heart journal · 2025Trial
- Revisiting the Effect of Udenafil on Exercise Performance in Patients With Fontan Circulation: Results of a Post Hoc Analysis of the FUEL Trial.Journal of the American Heart Association · 2025Trial
- Impact of Udenafil on Echocardiographic Indices of Single Ventricle Size and Function in FUEL Study Participants.Circulation. Cardiovascular imaging · 2022Trial
- Carvedilol Does Not Improve Exercise Performance in Fontan Patients: Results of a Crossover Trial.Pediatric cardiology · 2021Trial
- Results of the FUEL Trial.Circulation · 2020Trial
- Enhancing Cardiopulmonary Exercise Testing in Complex Congenital Heart Disease: The Role of Spirometry, Body Composition, and Handgrip Strength.Pediatric cardiology · 2026Review
- Impact of Inflow Ratio on a Double-Inflow Cavopulmonary Assist Device.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2026Article
- Exercise Capacity, Endothelial Function, Muscle Mass, and Strength in Pediatric Patients With Fontan Circulation.CJC pediatric and congenital heart disease · 2026Article
- Current concepts and challenges in pediatric diastolic dysfunction and heart failure with preserved ejection fraction.Pediatric research · 2026Review
- Article
- 30-Year Survival After the Fontan Operation in Denmark.Pediatric cardiology · 2026Article
- Are Arrhythmias Adequately Incorporated into Studies on Long-Term Outcomes After the Fontan Operation?Pediatric cardiology · 2026Review
- Early cardiac rehabilitation in ICU for infants after complex congenital heart disease surgery: a retrospective case series.Frontiers in pediatrics · 2026Article
- Association of Child Opportunity Index with Outcomes in Pediatric Supraventricular Tachycardia.Pediatric cardiology · 2026Article
- Lower Child Opportunity Index is Associated with Lower Exercise Capacity Post-Fontan Palliation.Pediatric cardiology · 2026Article
- Protocol for non-invasive assessment of skeletal muscle structure and function in adolescents with single ventricle heart disease: a cross-sectional, case-control study.Frontiers in cardiovascular medicine · 2026Article
- Predictors of Superior Exercise Performance in Patients Following Fontan Palliation.Pediatric cardiology · 2025Article
55 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors at 12 institutions in 2 countries.
Funding
Abstract
backgroundMulticenter longitudinal objective data for survival into adulthood of patients who have undergone Fontan procedures are lacking.
objectivesThis study sought to describe transplant-free survival and explore relationships between laboratory measures of ventricular performance and functional status over time.
methodsExercise testing, echocardiography, B-type natriuretic peptide, functional health assessment, and medical history abstraction were repeated 9.4 ± 0.4 years after the Fontan Cross-Sectional Study (Fontan 1) and compared with previous values. Cox regression analysis explored risk factors for interim death or cardiac transplantation.
resultsFrom the original cohort of 546 subjects, 466 were contacted again, and 373 (80%) were enrolled at 21.2 ± 3.5 years of age. Among subjects with paired testing, the percent predicted maximum oxygen uptake decreased (69 ± 14% vs. 61 ± 16%; p < 0.001; n = 95), ejection fraction decreased (58 ± 11% vs. 55 ± 10%; p < 0.001; n = 259), and B-type natriuretic peptide increased (median [interquartile range] 13 [7 to 25] pg/mol vs. 18 [9 to 36] pg/mol; p < 0.001; n = 340). At latest follow-up, a lower Pediatric Quality of Life Inventory physical summary score was associated with poorer exercise performance (R
conclusionsInterim transplant-free survival over 12 years in this Fontan cohort was 90% and was independent of ventricular morphology. Exercise performance decreased and was associated with worse functional health status. Future interventions might focus on preserving exercise capacity. (Relationship Between Functional Health Status and Ventricular Performance After Fontan-Pediatric Heart Network; NCT00132782).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.