Evidence map›Paper›PMID 28571527›Full record

ReviewThe journal of spinal cord medicine2017

Assessment and management of acute spinal cord injury: From point of injury to rehabilitation.

Laureen D Hachem, Christopher S Ahuja, Michael G Fehlings

2 registry-linked trialsOpen access · greenAbstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The journal of spinal cord medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 153 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
153citing papers in PubMed, 3 pooled it
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04316195 unknown statusnot on this mapstarted 2020, after this paper: background citation

Electromyographic Evaluation of the Bulbocavernosus Reflex After Acute Spinal Cord Injury: a New Prognostic Concept

Typeobservational_patient_registrySponsorAndréane Richard-DenisRan2020 to 2021Enrolled20ConditionsBulbocavernosus Reflex, Spinal Cord InjuriesArmsAssessment of the bulbocavernosus reflex
NCT04823078 nacompletednot on this mapstarted 2019, after this paper: background citation

Effects of Activity Based Therapy on Upper Limb Strength and Transfer in Spinal Cord Injury Patients

TypeinterventionalSponsorRiphah International UniversityRan2019 to 2020Enrolled16ConditionsSpinal Cord InjuriesArmsActivity base therapy, Strength training
3 · Its place in the literature

Who cites it

153 citing papers in PubMed, 3 syntheses or guidelines pooled it, 355 citations in OpenAlex.

  1. The neuroprotective role of riluzole in spinal cord injury: a systematic review and meta-analysis.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025
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  7. Energy cost and psychological impact of robotic-assisted gait training in people with spinal cord injury: effect of two different types of devices.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
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93 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 3 countries.

Laureen D Hachemb Institute of Medical Science, University of Toronto , Toronto , ONT , Canada.
Christopher S Ahujaa Division of Neurosurgery, Department of Surgery , University of Toronto , Toronto , ONT , Canada.
Michael G Fehlingsa Division of Neurosurgery, Department of Surgery , University of Toronto , Toronto , ONT , Canada.ORCID 0000-0002-5722-6364
University of Toronto · CA

Funding

CIHR MOP 123519
6 · The paper itself

Abstract

contextSpinal cord injury (SCI) is a devastating condition that can lead to significant neurological impairment and reduced quality of life. Despite advancements in our understanding of the pathophysiology and secondary injury mechanisms involved in SCI, there are currently very few effective treatments for this condition. The field, however, is rapidly changing as new treatments are developed and key discoveries are made.

methodsIn this review, we outline the pathophysiology, management, and long-term rehabilitation of individuals with traumatic SCI. We also provide an in-depth overview of emerging therapies along the spectrum of the translational pipeline. EVIDENCE SYNTHESIS: The concept of "time is spine" refers to the concept which emphasizes the importance of early transfer to specialized centers, early decompressive surgery, and early delivery of other treatments (e.g. blood pressure augmentation, methylprednisolone) to affect long-term outcomes. Another important evolution in management has been the recognition and prevention of the chronic complications of SCI including respiratory compromise, bladder dysfunction, Charcot joints, and pressure sores through directed interventions along with early integration of physical rehabilitation and mobilization. There have also been significant advances in neuroprotective and neuroregenerative strategies for SCI, many of which are actively in clinical trial including riluzole, Cethrin, stem cell transplantation, and the use of functional electrical stimulation.

conclusionPharmacologic treatments, cell-based therapies, and other technology-driven interventions will likely play a combinatorial role in the evolving management of SCI as the field continues to evolve.

Indexed as

AdultHumansMaleNeuralgiaNeurological RehabilitationPostoperative ComplicationsSpinal Cord InjuriesSpinal FusionSyringomyeliaUrinary Bladder, NeurogenicNeuroprotectionPathophysiologyRegenerationRehabilitationSpinal cord injuryStem cellSurgical decompressionTreatment

Identifiers

PMID28571527
PMCPMC5778930
OpenAlexW2620759028

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.