ArticleJournal of dental research2017
Targeting of Streptococcus mutans Biofilms by a Novel Small Molecule Prevents Dental Caries and Preserves the Oral Microbiome.
Article in Journal of dental research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 83 citations in OpenAlex.
- An in vitro comparison of cold atmospheric plasma and methylene blue-mediated antimicrobial photodynamic therapy with 660 nm laser on Streptococcus mutans biofilms.Lasers in medical science · 2026Article
- Effects of Berberine chloride hydrate on cariogenic multispecies streptococcal biofilm.Journal of oral microbiology · 2026Article
- Sodium houttuyfonate inhibits the cariogenic virulence ofJournal of oral microbiology · 2025Article
- Polymer vesicles for the delivery of inhibitors of cariogenic biofilm.Dental materials : official publication of the Academy of Dental Materials · 2024Article
- Intraspecies interactions ofmSphere · 2024Article
- Inhibitory and preventive effects of Arnebia euchroma (Royle) Johnst. root extract on Streptococcus mutans and dental caries in rats.BDJ open · 2024Article
- The Evolving Microbiome of Dental Caries.Microorganisms · 2024Review
- The antimicrobial effect of different vitamin D compounds onJournal of oral microbiology · 2024Article
- Intraspecies interactions ofbioRxiv : the preprint server for biology · 2023Article
- Microbial Biofilm: A Review on Formation, Infection, Antibiotic Resistance, Control Measures, and Innovative Treatment.Microorganisms · 2023Review
- [Materials for Selective Inhibition ofSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2022Review
- Review
- Plant Extract-Synthesized Silver Nanoparticles for Application in Dental Therapy.Pharmaceutics · 2022Review
- Synthesis, characterization and evaluation of azobenzene nanogels for their antibacterial properties in adhesive dentistry.European journal of oral sciences · 2022Article
- Novel antimicrobial agents targeting theFrontiers in cellular and infection microbiology · 2022Review
- The Application of Small Molecules to the Control of Typical Species Associated With Oral Infectious Diseases.Frontiers in cellular and infection microbiology · 2022Review
- The vicK gene of Streptococcus mutans mediates its cariogenicity via exopolysaccharides metabolism.International journal of oral science · 2021Article
- Small Molecule Compounds, A Novel Strategy againstPathogens (Basel, Switzerland) · 2021Review
- BiG-MAP: an Automated Pipeline To Profile Metabolic Gene Cluster Abundance and Expression in Microbiomes.mSystems · 2021Article
- Cariogenic Biofilm: Pathology-Related Phenotypes and Targeted Therapy.Microorganisms · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Dental caries is a costly and prevalent disease characterized by the demineralization of the tooth's enamel. Disease outcome is influenced by host factors, dietary intake, cariogenic bacteria, and other microbes. The cariogenic bacterial species Streptococcus mutans metabolizes sucrose to initiate biofilm formation on the tooth surface and consequently produces lactic acid to degrade the tooth's enamel. Persistence of S. mutans biofilms in the oral cavity can lead to tooth decay. To date, no anticaries therapies that specifically target S. mutans biofilms but do not disturb the overall oral microbiome are available. We screened a library of 2-aminoimidazole antibiofilm compounds with a biofilm dispersion assay and identified a small molecule that specifically targets S. mutans biofilms. At 5 µM, the small molecule annotated 3F1 dispersed 50% of the established S. mutans biofilm but did not disperse biofilms formed by the commensal species Streptococcus sanguinis or Streptococcus gordonii. 3F1 dispersed S. mutans biofilms independently of biofilm-related factors such as antigen I/II and glucosyltransferases. 3F1 treatment effectively prevented dental caries by controlling S. mutans in a rat caries model without perturbing the oral microbiota. Our study demonstrates that selective targeting of S. mutans biofilms by 3F1 was able to effectively reduce dental caries in vivo without affecting the overall oral microbiota shaped by the intake of dietary sugars, suggesting that the pathogenic biofilm-specific treatment is a viable strategy for disease prevention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.