Evidence map›Paper›PMID 28571325›Full record

ArticleBiointerphases2017

Poly(ethylene) glycol hydrogel based on oxa-Michael reaction: Precursor synthesis and hydrogel formation.

Hanqi Wang, Fang Cheng, Wei He, Jiaohui Zhu, Gang Cheng, Jingping Qu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biointerphases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hanqi WangState Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, Liaoning 116023, China and School of Pharmaceutical Science and Technology, Dalian University of Technology, Dalian, Liaoning 116023, China.
Fang ChengState Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, Liaoning 116023, China and School of Pharmaceutical Science and Technology, Dalian University of Technology, Dalian, Liaoning 116023, China.
Wei HeState Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, Liaoning 116023, China and Department of Polymer Science and Engineering, School of Chemical Engineering, Dalian University of Technology, Dalian, Liaoning 116023, China.
Jiaohui ZhuState Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, Liaoning 116023, China and School of Pharmaceutical Science and Technology, Dalian University of Technology, Dalian, Liaoning 116023, China.
Gang ChengDepartment of Chemical Engineering, University of Illinois at Chicago, Chicago, Illinois 60607.
Jingping QuState Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, Liaoning 116023, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This paper reported a facile strategy for the one-pot synthesis of vinyl sulfone (VS) group terminated hydrogel precursors [poly(ethylene) glycol (PEG)-VS] and PEG hydrogels via catalytic oxa-Michael reaction. Nine potential catalysts were investigated for the reaction between PEG and divinyl sulfone, among which 4-dimethylaminopyridine (DMAP) prevailed for its high catalytic activity. DMAP produced PEG-VS with a conversion of more than 90% in 2 h under a solvent-free condition at room temperature, which significantly simplifies the synthesis of PEG-VS. The preparation of PEG hydrogels was realized by adding glycerol as a crosslinker, and the physical and the mechanical properties were easily controlled by changing the crosslinker concentration as well as the PEG chain length. This strategy can also be applied to other polyhydroxy compounds as crosslinkers, and thus, a library of hydrogels with designed structures and desired properties could be prepared. The PEG hydrogels showed good antifouling properties, low cytotoxicity, and ability to release drugs at a tunable rate, indicating versatile potential bioapplications.

Indexed as

AnimalsCattleHydrogelsMaterials TestingPolyethylene GlycolsPyridinesSerum Albumin, BovineSulfones4-(dimethylamine)pyridinedivinyl sulfoneHydrogelsPolyethylene GlycolsPyridinesSerum Albumin, BovineSulfones

Identifiers

PMID28571325
PMCPMC5453855

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.