ArticleJournal of biomedical materials research. Part A2017
Comparison of the effects of 45S5 and 1393 bioactive glass microparticles on hMSC behavior.
Article in Journal of biomedical materials research. Part A, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Advances in Composite Bioactive Scaffolds for Alveolar Bone Repair: Implications for Oral Surgery.Brazilian dental journal · 2026Review
- Evaluating cell viability assessment techniques: a comparative study of flow cytometry and fluorescence microscopy in response to bioactive glass exposure.Biomedical engineering online · 2025Article
- Impact of 45S5-Bioactive Glass on Chondrocytes in Knee Osteoarthritis-In Vitro Study Exploring Cellular Responses.Journal of functional biomaterials · 2025Article
- Gelatin/Cerium-Doped Bioactive Glass Composites for Enhancing Cellular Functions of Human Mesenchymal Stem Cells (hBMSCs).Gels (Basel, Switzerland) · 2025Article
- Bioactive glass 1393 promotes angiogenesis and accelerates wound healing through ROS/P53/MMP9 signaling pathway.Regenerative therapy · 2024Article
- Bioactive glass-based fibrous wound dressings.Burns & trauma · 2022Review
- Artificial Extracellular Matrices Containing Bioactive Glass Nanoparticles Promote Osteogenic Differentiation in Human Mesenchymal Stem Cells.International journal of molecular sciences · 2021Article
- An In Vitro Evaluation of the Biological and Osteogenic Properties of Magnesium-Doped Bioactive Glasses for Application in Bone Tissue Engineering.International journal of molecular sciences · 2021Article
- Manipulating Air-Gap Electrospinning to Create Aligned Polymer Nanofiber-Wrapped Glass Microfibers for Cortical Bone Tissue Engineering.Bioengineering (Basel, Switzerland) · 2020Article
- In Vivo Validation of Spray-Dried Mesoporous Bioactive Glass Microspheres Acting as Prolonged Local Release Systems for BMP-2 to Support Bone Regeneration.Pharmaceutics · 2020Article
- Strontium-releasing mesoporous bioactive glasses with anti-adhesive zwitterionic surface as advanced biomaterials for bone tissue regeneration.Journal of colloid and interface science · 2020Article
- Superior biocompatibility and comparable osteoinductive properties: Sodium-reduced fluoride-containing bioactive glass belonging to the CaO-MgO-SiOBioactive materials · 2020Article
- Bioactive Glass (BG) ICIE16 Shows Promising Osteogenic Properties Compared to Crystallized 45S5-BG.International journal of molecular sciences · 2020Article
- ZIF-8 Modified Polypropylene Membrane: A Biomimetic Cell Culture Platform with a View to the Improvement of Guided Bone Regeneration.International journal of nanomedicine · 2020Article
- Biological Properties of Calcium Phosphate Bioactive Glass Composite Bone Substitutes: Current Experimental Evidence.International journal of molecular sciences · 2019Review
- Bioinks and bioprinting technologies to make heterogeneous and biomimetic tissue constructs.Materials today. Bio · 2019Review
- Bioprinting with human stem cell-laden alginate-gelatin bioink and bioactive glass for tissue engineering.International journal of bioprinting · 2019Article
- Optimization of cell-laden bioinks for 3D bioprinting and efficient infection with influenza A virus.Scientific reports · 2018Article
- Synthesis and characterization of manganese containing mesoporous bioactive glass nanoparticles for biomedical applications.Journal of materials science. Materials in medicine · 2018Article
- Comparison of the effects of 45S5 and 1393 bioactive glass microparticles on hMSC behavior.Journal of biomedical materials research. Part A · 2017Article
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6 authors.
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Abstract
Bioactive glasses (BAGs) are highly interesting materials for bone regeneration applications in orthopedic and dental defects. It is quite well known that ionic release from BAGs influences cell behavior and function. Mindful of the clinical scenario, we hypothesized that local cell populations might additionally physically interact with the implanted BAG particles and respond differently than to just the ionic stimuli. We therefore studied the biological effect of two BAG types (45S5 and 1393) applied to human mesenchymal stromal cells (hMSCs) in three distinct presentation modes: (a) direct contact; and to dissolution products in (b) 2D, and (c) 3D culture. We furthermore investigated how the dose-dependence of these BAG particles, in concentrations ranging from 0.1 to 2.5 w/v %, influenced hMSC metabolic activity, proliferation, and cell spreading. These cellular functions were significantly hampered when hMSCs were exposed to high concentrations of either glasses, but the effects were more pronounced in the 45S5 groups and when the cells were in direct contact with the BAGs. Furthermore the biological effect of 1393 BAG outperformed that of 45S5 BAG in all tested presentation modes. These outcomes highlight the importance of investigating cell-BAG interactions in experimental set-ups that recapitulate host cell interactions with BAG particles. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2772-2782, 2017.
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