Evidence map›Paper›PMID 28570966›Full record

Trial reportJournal of affective disorders2017

Enhancing quality of life among adolescents with bipolar disorder: A randomized trial of two psychosocial interventions.

Lisa A O'Donnell, David A Axelson, Robert A Kowatch, Christopher D Schneck, Catherine A Sugar, David J Miklowitz

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of affective disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Home-based transcranial direct current stimulation (tDCS) for bipolar depression: effects on quality of life and functioning-an open-label study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
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  10. "What makes you well?" Supports of well-being in bipolar disorder. A qualitative study.International journal of qualitative studies on health and well-being · 2023
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  11. The role of family functioning and self-esteem in the quality of life of adolescents referred for psychiatric services: a 3-year follow-up.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2019
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  12. Improving Functioning, Quality of Life, and Well-being in Patients With Bipolar Disorder.The international journal of neuropsychopharmacology · 2019
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  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lisa A O'DonnellSemel Institute, University of California, Los Angeles, CA, USA. Electronic address: LOdonnell@mednet.umich.edu.
David A AxelsonThe Ohio State University College of Medicine, Columbus, OH, USA.
Robert A KowatchThe Ohio State University College of Medicine, Columbus, OH, USA.
Christopher D SchneckUniversity of Colorado School of Medicine, Aurora, CO, USA.
Catherine A SugarSemel Institute, University of California, Los Angeles, CA, USA.
David J MiklowitzSemel Institute, University of California, Los Angeles, CA, USA.

Funding

1/2-Early Intervention for Youth at Risk for Bipolar DisorderR01MH093676 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKLOWITZ, DAVID JAY · 2012 to 2016
$3.6M
Family-Focused Treatment for Bipolar AdolescentsR01MH073871 · NIMH · UNIVERSITY OF COLORADO · PI MIKLOWITZ, DAVID JAY · 2006 to 2010
$1.7M
Family-Focused Treatment for Youth with Early-Onset Bipolar or Psychotic DisorderR21MH097007 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKLOWITZ, DAVID JAY · 2012 to 2013
$439k
NIMH NIH HHS R01 MH073871NIMH NIH HHS R01 MH093676NIMH NIH HHS R21 MH097007
6 · The paper itself

Abstract

backgroundAdolescents with bipolar disorder (BD) report lower quality of life (QoL) than adolescents with other psychiatric disorders. This study compared the efficacy of family-focused therapy for adolescents (FFT-A) plus pharmacotherapy to brief psychoeducation (enhanced care, or EC) plus pharmacotherapy on self-rated QoL in adolescents with BD over 2 years.

methodsParticipants were 141 adolescents (mean age: 15.6±1.4yr) with BD I or II who had a mood episode in the previous 3 months. Adolescents and parents were randomly assigned to (1) FFT-A, given in 21 sessions in 9 months of psychoeducation, communication enhancement training, and problem-solving skills training, or (2) EC, given in 3 family psychoeducation sessions. Study psychiatrists provided patient participants with protocol-based pharmacotherapy for the duration of the study. QoL was assessed with The KINDL

resultsThe two treatment groups did not differ in overall QoL scores over 24 months. However, adolescents in FFT-A had greater improvements in quality of family relationships and physical well-being than participants in EC. For quality of friendships, the trajectory during active treatment favored EC, whereas the trajectory during post-treatment favored FFT-A. LIMITATIONS: We were unable to standardize medication use or adherence over time. Quality of life was based on self-report rather than on observable functioning.

conclusionsA short course of family psychoeducation and skills training may enhance relational functioning and health in adolescents with BD. The effects of different psychosocial interventions on peer relationships deserves further study.

Indexed as

AdolescentAntipsychotic AgentsBipolar DisorderCombined Modality TherapyCommunicationFamily RelationsFamily TherapyFemaleHumansMalePatient Education as TopicQuality of LifeTreatment OutcomeAntipsychotic AgentsChildhood-onset bipolar disorderFamily interventionFunctional outcomesMood disordersPsychosocial functioning

Identifiers

PMID28570966
PMCPMC5915675

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.