Evidence map›Paper›PMID 28570933›Full record

ReviewCytokine2017

The Goldilocks model of immune symbiosis with Mycobacteria and Candida colonizers.

Richard T Robinson, Anna R Huppler

Abstract readReview
In one paragraph

Review in Cytokine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Microorganisms · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Facial Erythema Due to Lupus Vulgaris andClinical, cosmetic and investigational dermatology · 2022
    Article
  8. The Many Hosts of Mycobacteria 8 (MHM8): A conference report.Tuberculosis (Edinburgh, Scotland) · 2020
    Review
  9. Review
  10. Article
  11. Article
  12. The Child with Recurrent Mycobacterial Disease.Current allergy and asthma reports · 2018
    Review
  13. The many lives of nontuberculous mycobacteria.Journal of bacteriology · 2018
    Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Richard T RobinsonDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address: rrobinson@mcw.edu.
Anna R HupplerDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI, USA; Department of Pediatrics, Division of Infectious Disease, Medical College of Wisconsin, Children's Hospital and Health System, Children's Research Institute, Milwaukee, WI, USA. Electronic address: ahuppler@mcw.edu.

Funding

Regulation of human IL12/IL23 responsiveness by IL12RB1R01AI121212 · NIAID · OHIO STATE UNIVERSITY · PI ROBINSON, RICHARD · 2016 to 2020
$1.9M
Anti-Candida activity of CCL28 in oropharyngeal candidiasisK08DE026189 · NIDCR · MEDICAL COLLEGE OF WISCONSIN · PI HUPPLER, ANNA · 2017 to 2021
$860k
NIAID NIH HHS R01 AI121212NIDCR NIH HHS K08 DE026189
6 · The paper itself

Abstract

Mycobacteria and Candida species include significant human pathogens that can cause localized or disseminated infections. Although these organisms may appear to have little in common, several shared pathways of immune recognition and response are important for both control and infection-related pathology. In this article, we compare and contrast the innate and adaptive components of the immune system that pertain to these infections in humans and animal models. We also explore a relatively new concept in the mycobacterial field: biological commensalism. Similar to the well-established model of Candida infection, Mycobacteria species colonize their human hosts in equilibrium with the immune response. Perturbations in the immune response permit the progression to pathologic disease at the expense of the host. Understanding the immune factors required to maintain commensalism may aid with the development of diagnostic and treatment strategies for both categories of pathogens.

Indexed as

Adaptive ImmunityAnimalsCandidaCandidiasisDisease Models, AnimalHumansImmunity, InnateMycobacteriumSymbiosisTuberculosisCandidaCandidiasisCommensalMycobacteriaNontuberculousTuberculosis

Identifiers

PMID28570933
PMCPMC5765749

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.