ArticlePloS one2017
Exhaled volatile substances mirror clinical conditions in pediatric chronic kidney disease.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Exhaled volatile organic compounds analysis in clinical pediatrics: a systematic review.Pediatric research · 2021Pooled it
- Halitosis in young patients with chronic kidney disease: findings from a randomized controlled trial.Head & face medicine · 2024Trial
- The optical nose: Monolayer sensitization of Au surfaces for plasmonic gas sensing.Science advances · 2026Article
- Non-Invasive Diagnostic Approaches for Kidney Disease: The Role of Electronic Nose Systems.Sensors (Basel, Switzerland) · 2024Review
- Breath Analysis: Identification of Potential Volatile Biomarkers for Non-Invasive Diagnosis of Chronic Kidney Disease (CKD).Molecules (Basel, Switzerland) · 2024Observational
- Wireless Flexible System for Highly Sensitive Ammonia Detection Based on Polyaniline/Carbon Nanotubes.Biosensors · 2024Article
- The State of the Art on Graphene-Based Sensors for Human Health Monitoring through Breath Biomarkers.Sensors (Basel, Switzerland) · 2023Review
- Analysis of volatile organic compounds from deep airway in the lung through intubation sampling.Analytical and bioanalytical chemistry · 2022Article
- Exhaled Aldehydes as Biomarkers for Lung Diseases: A Narrative Review.Molecules (Basel, Switzerland) · 2022Review
- Utility of SIFT-MS to evaluate volatile organic compounds in nephropathic patients' breath.Scientific reports · 2022Article
- ptairMS: real-time processing and analysis of PTR-TOF-MS data for biomarker discovery in exhaled breath.Bioinformatics (Oxford, England) · 2022Article
- Photoacoustic detection of ammonia exhaled by individuals with chronic kidney disease.Lasers in medical science · 2022Article
- Volatile organic compounds: A proinflammatory activator in autoimmune diseases.Frontiers in immunology · 2022Review
- Hyphenated Mass Spectrometry versus Real-Time Mass Spectrometry Techniques for the Detection of Volatile Compounds from the Human Body.Molecules (Basel, Switzerland) · 2021Review
- Exhaled Breath Reflects Prolonged Exercise and Statin Use during a Field Campaign.Metabolites · 2021Article
- Volatile Organic Compounds, Bacterial Airway Microbiome, Spirometry and Exercise Performance of Patients after Surgical Repair of Congenital Diaphragmatic Hernia.Molecules (Basel, Switzerland) · 2021Article
- Assessing the feasibility and acceptability of online measurements of exhaled volatile organic compounds (VOCs) in children with preschool wheeze: a pilot study.BMJ paediatrics open · 2021Article
- Screening of Chorioamnionitis Using Volatile Organic Compound Detection in Exhaled Breath: A Pre-clinical Proof of Concept Study.Frontiers in pediatrics · 2021Article
- Breath Ammonia Is a Useful Biomarker Predicting Kidney Function in Chronic Kidney Disease Patients.Biomedicines · 2020Article
- Microbiota and Malodor-Etiology and Management.International journal of molecular sciences · 2020Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Monitoring metabolic adaptation to chronic kidney disease (CKD) early in the time course of the disease is challenging. As a non-invasive technique, analysis of exhaled breath profiles is especially attractive in children. Up to now, no reports on breath profiles in this patient cohort are available. 116 pediatric subjects suffering from mild-to-moderate CKD (n = 48) or having a functional renal transplant KTx (n = 8) and healthy controls (n = 60) matched for age and sex were investigated. Non-invasive quantitative analysis of exhaled breath profiles by means of a highly sensitive online mass spectrometric technique (PTR-ToF) was used. CKD stage, the underlying renal disease (HUS; glomerular diseases; abnormalities of kidney and urinary tract or polycystic kidney disease) and the presence of a functional renal transplant were considered as classifiers. Exhaled volatile organic compound (VOC) patterns differed between CKD/ KTx patients and healthy children. Amounts of ammonia, ethanol, isoprene, pentanal and heptanal were higher in patients compared to healthy controls (556, 146, 70.5, 9.3, and 5.4 ppbV vs. 284, 82.4, 49.6, 5.30, and 2.78 ppbV). Methylamine concentrations were lower in the patient group (6.5 vs 10.1 ppbV). These concentration differences were most pronounced in HUS and kidney transplanted patients. When patients were grouped with respect to degree of renal failure these differences could still be detected. Ammonia accumulated already in CKD stage 1, whereas alterations of isoprene (linked to cholesterol metabolism), pentanal and heptanal (linked to oxidative stress) concentrations were detectable in the breath of patients with CKD stage 2 to 4. Only weak associations between serum creatinine and exhaled VOCs were noted. Non-invasive breath testing may help to understand basic mechanisms and metabolic adaptation accompanying progression of CKD. Our results support the current notion that metabolic adaptation occurs early during the time course of CKD.
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