ArticlePLoS computational biology2017
Breakdown of local information processing may underlie isoflurane anesthesia effects.
Article in PLoS computational biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Ferret as a model system for studying the anatomy and function of the prefrontal cortex: A systematic review.Neuroscience and biobehavioral reviews · 2024Pooled it
- Criticality supports cross-frequency cortical-thalamic information transfer during conscious states.eLife · 2024Article
- Information-theoretic analyses of neural data to minimize the effect of researchers' assumptions in predictive coding studies.PLoS computational biology · 2023Article
- Neuronal connected burst cascades bridge macroscale adaptive signatures across arousal states.Nature communications · 2023Article
- Whole-brain analyses indicate the impairment of posterior integration and thalamo-frontotemporal broadcasting in disorders of consciousness.Human brain mapping · 2023Article
- Measures of Information Content during Anesthesia and Emergence in the Caenorhabditis elegans Nervous System.Anesthesiology · 2023Article
- Performance Baseline of Phase Transfer Entropy Methods for Detecting Animal Brain Area Interactions.Entropy (Basel, Switzerland) · 2023Article
- Arousal system stimulation and anesthetic state alter visuoparietal connectivity.Frontiers in systems neuroscience · 2023Article
- Information theoretic evidence for layer- and frequency-specific changes in cortical information processing under anesthesia.PLoS computational biology · 2023Article
- A Fast and Efficient Ensemble Transfer Entropy and Applications in Neural Signals.Entropy (Basel, Switzerland) · 2022Article
- Detection of Cause-Effect Relations Based on Information Granulation and Transfer Entropy.Entropy (Basel, Switzerland) · 2022Article
- Quantifying the Predictability of Visual Scanpaths Using Active Information Storage.Entropy (Basel, Switzerland) · 2021Article
- Measuring spectrally-resolved information transfer.PLoS computational biology · 2020Article
- What Can Local Transfer Entropy Tell Us about Phase-Amplitude Coupling in Electrophysiological Signals?Entropy (Basel, Switzerland) · 2020Article
- Dorsal prefrontal and premotor cortex of the ferret as defined by distinctive patterns of thalamo-cortical projections.Brain structure & function · 2020Article
- Desflurane Anesthesia Alters Cortical Layer-specific Hierarchical Interactions in Rat Cerebral Cortex.Anesthesiology · 2020Article
- Review
- Transfer Entropy as a Measure of Brain Connectivity: A Critical Analysis With the Help of Neural Mass Models.Frontiers in computational neuroscience · 2020Article
- Information estimation using nonparametric copulas.Physical review. E · 2018Article
- Predictable information in neural signals during resting state is reduced in autism spectrum disorder.Human brain mapping · 2018Article
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The disruption of coupling between brain areas has been suggested as the mechanism underlying loss of consciousness in anesthesia. This hypothesis has been tested previously by measuring the information transfer between brain areas, and by taking reduced information transfer as a proxy for decoupling. Yet, information transfer is a function of the amount of information available in the information source-such that transfer decreases even for unchanged coupling when less source information is available. Therefore, we reconsidered past interpretations of reduced information transfer as a sign of decoupling, and asked whether impaired local information processing leads to a loss of information transfer. An important prediction of this alternative hypothesis is that changes in locally available information (signal entropy) should be at least as pronounced as changes in information transfer. We tested this prediction by recording local field potentials in two ferrets after administration of isoflurane in concentrations of 0.0%, 0.5%, and 1.0%. We found strong decreases in the source entropy under isoflurane in area V1 and the prefrontal cortex (PFC)-as predicted by our alternative hypothesis. The decrease in source entropy was stronger in PFC compared to V1. Information transfer between V1 and PFC was reduced bidirectionally, but with a stronger decrease from PFC to V1. This links the stronger decrease in information transfer to the stronger decrease in source entropy-suggesting reduced source entropy reduces information transfer. This conclusion fits the observation that the synaptic targets of isoflurane are located in local cortical circuits rather than on the synapses formed by interareal axonal projections. Thus, changes in information transfer under isoflurane seem to be a consequence of changes in local processing more than of decoupling between brain areas. We suggest that source entropy changes must be considered whenever interpreting changes in information transfer as decoupling.
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