ArticlePloS one2017
Metabolomic and proteomic investigations of impacts of titanium dioxide nanoparticles on Escherichia coli.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 61 citations in OpenAlex.
- FTIR-ATR monitoring of growth-phase-dependent spectral responses ofRSC advances · 2026Article
- Microbial response and resistance mechanisms against diverse anthropogenic pollutants.Frontiers in microbiology · 2026Review
- Inflammatory effects of titanium dioxide nanoparticles against polymethyl methacrylate on the subcutaneous tissue of rabbits.Open veterinary journal · 2025Article
- Aquatic Fate and Ecotoxicology Effect of ZnS:Mn Quantum Dots onJournal of xenobiotics · 2024Article
- Aromatic amino acid metabolism and active transport regulation are implicated in microbial persistence in fractured shale reservoirs.ISME communications · 2024Article
- The toxicity of nanoparticles and their interaction with cells: anNanoscale advances · 2023Review
- Role of Platinum Nanozymes in the Oxidative Stress Response ofAntioxidants (Basel, Switzerland) · 2023Article
- Proteomics and Metabolomics Analysis Reveals the Toxicity of ZnO Quantum Dots on Human SMMC-7721 Cells.International journal of nanomedicine · 2023Article
- Sample Preparation in Microbial Metabolomics: Advances and Challenges.Advances in experimental medicine and biology · 2023Article
- Molecular phenotyping approaches for the detection and monitoring of carbapenem-resistant Enterobacteriaceae by mass spectrometry.Journal of mass spectrometry and advances in the clinical lab · 2022Review
- Nanoparticle Impact on the Bacterial Adaptation: Focus on Nano-Titania.Nanomaterials (Basel, Switzerland) · 2022Review
- Smoothies Reduce the "Bioaccessibility" of TiONutrients · 2022Article
- Factors Conditioning the Potential Effects TiO2 NPs Exposure on Human Microbiota: a Mini-Review.Biological trace element research · 2021Review
- Photocatalytic TiOIndian journal of microbiology · 2021Article
- Overview of Metabolomic Analysis and the Integration with Multi-Omics for Economic Traits in Cattle.Metabolites · 2021Review
- Four Types of TiOFoods (Basel, Switzerland) · 2021Article
- Identification of Quinone Degradation as a Triggering Event for Intense Pulsed Light-Elicited Metabolic Changes inMetabolites · 2021Article
- Comparative genomics and metabolomics analysis of Riemerella anatipestifer strain CH-1 and CH-2.Scientific reports · 2021Article
- Molecular Mechanisms of Nanomaterial-Bacterial Interactions Revealed by Omics-The Role of Nanomaterial Effect Level.Frontiers in bioengineering and biotechnology · 2021Review
- Ecological and toxicological assessments of anthropogenic contaminants based on environmental metabolomics.Environmental science and ecotechnology · 2021Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In a previous study, it was demonstrated that the toxic impact of titanium dioxide nanoparticles on Escherichia coli starts at 10 ppm and is closely related to the presence of little aggregates. It was also assumed that only a part of the bacterial population is able to adapt to this stress and attempts to survive. Proteomic analyses, supported by results from metabolomics, reveal that exposure of E. coli to nano-TiO2 induces two main effects on bacterial metabolism: firstly, the up-regulation of proteins and the increase of metabolites related to energy and growth metabolism; secondly, the down-regulation of other proteins resulting in an increase of metabolites, particularly amino acids. Some proteins, e.g. chaperonin 1 or isocitrate dehydrogenase, and some metabolites, e.g. phenylalanine or valine, might be used as biomarkers of nanoparticles stress. Astonishingly, the ATP content gradually rises in relation with the nano-TiO2 concentration in the medium, indicating a dramatic release of ATP by the damaged cells. These apparently contradictory results accredit the thesis of a heterogeneity of the bacterial population. This heterogeneity is also confirmed by SEM images which show that while some bacteria are fully covered by nano-TiO2, the major part of the bacterial population remains free from nanoparticles, resulting in a difference of proteome and metabolome. The use of combined-omics has allowed to better understand the heterogeneous bacterial response to nano-TiO2 stress due to heterogeneous contacts between the protagonists under environmental conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.