ArticleJournal of visualized experiments : JoVE2017
Methods to Classify Cytoplasmic Foci as Mammalian Stress Granules.
Article in Journal of visualized experiments : JoVE, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Article
- Chronic stress antagonizes formation of stress granules.iScience · 2026Article
- Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates.Cell · 2025Article
- Nuclear RNA-related processes modulate the assembly of cytoplasmic RNA granules.Nucleic acids research · 2024Article
- Apurinic/apyrimidinic endodeoxyribonuclease 1 (APE1) promotes stress granule formation via YBX1 phosphorylation in ovarian cancer.Cellular and molecular life sciences : CMLS · 2024Article
- Article
- Translation inhibition and suppression of stress granules formation by cisplatin.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022Article
- Translational control by helicases during cellular stress.Methods in enzymology · 2022Article
- Defining the Caprin-1 Interactome in Unstressed and Stressed Conditions.Journal of proteome research · 2021Article
- Tellurite Promotes Stress Granules and Nuclear SG-Like Assembly in Response to Oxidative Stress and DNA Damage.Frontiers in cell and developmental biology · 2021Article
- RNase L Amplifies Interferon Signaling by Inducing Protein Kinase R-Mediated Antiviral Stress Granules.Journal of virology · 2020Article
- Regulation of Stress Granule Formation by Inflammation, Vascular Injury, and Atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2019Article
- The TRAPP complex mediates secretion arrest induced by stress granule assembly.The EMBO journal · 2019Article
- PRMT7 methylates eukaryotic translation initiation factor 2α and regulates its role in stress granule formation.Molecular biology of the cell · 2019Article
- Nitric oxide triggers the assembly of "type II" stress granules linked to decreased cell viability.Cell death & disease · 2018Article
- Disease of mRNA Regulation: Relevance for Ischemic Brain Injury.Translational stroke research · 2018Review
- Identification of functional tetramolecular RNA G-quadruplexes derived from transfer RNAs.Nature communications · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Cells are often challenged by sudden environmental changes. Stress Granules (SGs), cytoplasmic ribonucleoprotein complexes that form in cells exposed to stress conditions, are implicated in various aspects of cell metabolism and survival. SGs modulate cellular signaling pathways, post-transcriptional gene expression, and stress response programs. The formation of these mRNA-containing granules is directly connected to cellular translation. SG assembly is triggered by inhibited translation initiation, and SG disassembly is promoted by translation activation or by inhibited translation elongation. This relationship is further highlighted by SG composition. Core SG components are stalled translation pre-initiation complexes, mRNA, and selected RNA-binding Proteins (RBPs). The purpose of SG assembly is to conserve cellular energy by sequestering translationally stalled housekeeping mRNAs, allowing for the enhanced translation of stress-responsive proteins. In addition to the core constituents, such as stalled translation preinitiation complexes, SGs contain a plethora of other proteins and signaling molecules. Defects in SG formation can impair cellular adaptation to stress and can thus promote cell death. SGs and similar RNA-containing granules have been linked to a number of human diseases, including neurodegenerative disorders and cancer, leading to the recent interest in classifying and defining RNA granule subtypes. This protocol describes assays to characterize and quantify mammalian SGs.
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Registered trials
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