Evidence map›Paper›PMID 28569665›Full record

ArticleeLife2017

A vitamin-B2-sensing mechanism that regulates gut protease activity to impact animal's food behavior and growth.

Bin Qi, Marina Kniazeva, Min Han

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 95 citations in OpenAlex.

  1. Green-ExtractedAntioxidants (Basel, Switzerland) · 2026
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  2. High-Throughput Toxicity Screening withEnvironmental science & technology · 2026
    Review
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  14. Studying the mechanisms of neurodegeneration:Frontiers in cellular neuroscience · 2025
    Review
  15. Article
  16. Article
  17. Article
  18. UPReLife · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Bin QiDepartment of Molecular, Cellular and Developmental Biology, Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, United States.ORCID 0000-0003-1507-8882
Marina KniazevaDepartment of Molecular, Cellular and Developmental Biology, Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, United States.
Min HanDepartment of Molecular, Cellular and Developmental Biology, Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, United States.ORCID 0000-0001-6845-2570
Howard Hughes Medical Institute · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

To survive challenging environments, animals acquired the ability to evaluate food quality in the intestine and respond to nutrient deficiencies with changes in food-response behavior, metabolism and development. However, the regulatory mechanisms underlying intestinal sensing of specific nutrients, especially micronutrients such as vitamins, and the connections to downstream physiological responses in animals remain underexplored. We have established a system to analyze the intestinal response to vitamin B

Indexed as

Adenosine TriphosphateAnimalsCaenorhabditis elegansFeeding BehaviorGastrointestinal TractMechanistic Target of Rapamycin Complex 1Peptide HydrolasesRiboflavinSignal TransductionAdenosine TriphosphateMechanistic Target of Rapamycin Complex 1Peptide HydrolasesRiboflavinATP sensingC. elegansdevelopmental biologyenergy metabolismFADnutrient sensingRiboflavinstem cellsTOR

Identifiers

PMID28569665
PMCPMC5478268
OpenAlexW2620966823

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.