Effects of chronic exposure to triclosan on reproductive and thyroid endpoints in the adult Wistar female rat.

Gwendolyn W Louis, Daniel R Hallinger, M Janay Braxton, Alaa Kamel, Tammy E Stoker

Open access · greenAbstract read

In one paragraph

Article in Journal of toxicology and environmental health. Part A, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it

0cells of the map it votes in

13citing papers in PubMed

3.4field-weighted citation impact, top 8% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 45 citations in OpenAlex.

Gestational Exposure to Perchlorate in the Rat: Thyroid Hormones in Fetal Thyroid Gland, Serum, and Brain.Toxicological sciences : an official journal of the Society of Toxicology · 2022
Article
Thyroid Disruptors: Extrathyroidal Sites of Chemical Action and Neurodevelopmental Outcome-An Examination Using Triclosan and Perfluorohexane Sulfonate.Toxicological sciences : an official journal of the Society of Toxicology · 2021
Article
Regulation of Thyroid-disrupting Chemicals to Protect the Developing Brain.Endocrinology · 2020
Review
Perinatal Exposure to Triclosan Results in Abnormal Brain Development and Behavior in Mice.International journal of molecular sciences · 2020
Article
Extrapolating In Vitro Screening Assay Data for Thyroperoxidase Inhibition to Predict Serum Thyroid Hormones in the Rat.Toxicological sciences : an official journal of the Society of Toxicology · 2020
Article
Early-life triclosan exposure and parent-reported behavior problems in 8-year-old children.Environment international · 2019
Article
The Widely Used Antimicrobial Triclosan Induces High Levels of Antibiotic ToleranceAntimicrobial agents and chemotherapy · 2019
Article
A repeated measures study of phenol, paraben and Triclocarban urinary biomarkers and circulating maternal hormones during gestation in the Puerto Rico PROTECT cohort.Environmental health : a global access science source · 2019
Article
Evaluation of triclosan in the Hershberger and H295R steroidogenesis assays.Toxicology letters · 2018
Article
Identifying Vulnerable Periods of Neurotoxicity to Triclosan Exposure in Children.Environmental health perspectives · 2018
Article
Associations of early life urinary triclosan concentrations with maternal, neonatal, and child thyroid hormone levels.Hormones and behavior · 2018
Article
Triclosan exposure, transformation, and human health effects.Journal of toxicology and environmental health. Part B, Critical reviews · 2017
Review
An optimized radioimmunoassay for quantification of total serum thyroxine (T4) in fetal, neonatal, and pregnant rats.Neurotoxicology and teratology
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Gwendolyn W Louisa Endocrine Toxicology Branch, Toxicity Assessment Division , National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. EPA , Research Triangle Park , NC , USA.

Daniel R Hallingera Endocrine Toxicology Branch, Toxicity Assessment Division , National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. EPA , Research Triangle Park , NC , USA.

M Janay Braxtona Endocrine Toxicology Branch, Toxicity Assessment Division , National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. EPA , Research Triangle Park , NC , USA.

Alaa Kamelc Analytical Chemistry Branch, Biological and Economic Analysis Division , Office of Pesticide Programs, U.S. EPA, Fort Meade , MD , USA.

Tammy E Stokera Endocrine Toxicology Branch, Toxicity Assessment Division , National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. EPA , Research Triangle Park , NC , USA.

Environmental Protection Agency · USResearch Triangle Park Foundation · USCalifornia Department of Pesticide Regulation · US

Funding

Intramural EPA EPA999999

6 · The paper itself

Abstract

Triclosan (TCS), an antibacterial, has been shown to be an endocrine disruptor in the rat. Previously, subchronic TCS treatment to female rats was found to advance puberty and potentiate the effect of ethinyl estradiol (EE) on uterine growth when EE and TCS were co-administered prior to weaning. In the pubertal study, a decrease in serum thyroxine (T

Indexed as

AgingAnimalsAnti-Infective Agents, LocalEstrous CycleFemaleHypothalamo-Hypophyseal SystemRatsRats, WistarReproductionThyroid GlandToxicity Tests, ChronicTriclosanAnti-Infective Agents, LocalTriclosan

Identifiers

PMID28569618

DOI10.1080/15287394.2017.1287029

PMCPMC5994608

OpenAlexW2621365346

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.