ArticleLasers in medical science2017
Radiofrequency treatment induces fibroblast growth factor 2 expression and subsequently promotes neocollagenesis and neoangiogenesis in the skin tissue.
Article in Lasers in medical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Effects of Non-Invasive Radiofrequency Diathermy in Pelvic Floor Disorders: A Systematic Review.Medicina (Kaunas, Lithuania) · 2022Pooled it
- Innovative Facial Contouring Using a Monopolar Radiofrequency Device with Continuous Water Cooling: An Integrated Clinical and Preclinical Study.International journal of molecular sciences · 2026Trial
- Monopolar Radiofrequency for Facial Hyperpigmentation Treatment: An Integrated Retrospective Clinical Trial and Ex Vivo Study.International journal of molecular sciences · 2026Trial
- A Novel Technology to Boost Natural Production of Hyaluronic Acid in the Skin Tissue: Human Histology Study.Journal of cosmetic dermatology · 2025Trial
- Radiofrequency for the Treatment of Facial Ligament Laxity: A Split-face Controlled Exploratory Study.Plastic and reconstructive surgery. Global open · 2026Article
- Improvement of signs of vulvovaginal chronic graft-versus-host disease and genital syndrome of menopause with non-ablative radiofrequency therapy.Bone marrow transplantation · 2026Article
- Short-term safety and preliminary patient-reported outcomes of bipolar radiofrequency therapy for mild-to-moderate erectile dysfunction: a prospective single-arm pilot study.Translational andrology and urology · 2026Article
- Body Shaping and Skin Appearance Improvement in the Abdomen and Flanks by Radiofrequency Technology.Lasers in surgery and medicine · 2025Article
- The Clinical Impact of Different Cryolipolysis Protocols: An Integrative Review.Aesthetic plastic surgery · 2025Review
- Clinical Evaluation of a Combination of Non-Invasive Technologies to Improve the Effectiveness of Postpartum Abdominal Treatment.Journal of cosmetic dermatology · 2025Article
- Electromagnetic Fields, Electrical Stimulation, and Vacuum Simultaneously Applied for Major Burn Scars.Bioengineering (Basel, Switzerland) · 2025Article
- Novel Applicator Utilizing HIFES and Enhanced Synchronized Radiofrequency+ for Subcutaneous Fat Reduction: Porcine Model Study.Lasers in surgery and medicine · 2024Article
- Transcriptomic Analysis of Blood Collagen-Induced Arthritis Mice Exposed to 0.1 THz Reveals Inhibition of Genes and Pathways Involved in Rheumatoid Arthritis.International journal of molecular sciences · 2024Article
- Radiofrequency energy in the treatment of erectile dysfunction-a novel cohort pilot study on safety, applicability, and short-term efficacy.International journal of impotence research · 2024Article
- Radiofrequency Currents Modulate Inflammatory Processes in Keratinocytes.International journal of molecular sciences · 2024Article
- Effects of RF Electric Currents on Hair Follicle Growth and Differentiation: A Possible Treatment for Alopecia.International journal of molecular sciences · 2024Article
- The Superior Effect of Radiofrequency With Targeted Ultrasound for Facial Rejuvenation by Inducing Hyaluronic Acid Synthesis: A Pilot Preclinical Study.Aesthetic surgery journal. Open forum · 2024Article
- Anti-Fibrotic Effects of RF Electric Currents.International journal of molecular sciences · 2023Article
- Novel Nonablative Radiofrequency Approach for the Treatment of Anal Incontinence: A Phase 1 Clinical Trial.Cureus · 2023Article
- Effect of Extracorporeal Shock Waves on Induced Neocollagenesis of Integumentary Tissue.The Journal of clinical and aesthetic dermatology · 2022Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Radiofrequency (RF) treatment appears to be involved in production of new collagen fibrils and the improvement of existing collagen structures; however, the molecular bases of the effect of non-invasive RF on the skin tissue have not been fully elucidated. This study reports the effects of RF associated or not with hydrolyzed collagen (HC) in the skin tissue. Wistar rats were randomly divided into four groups, according to the treatment received: control group (G1, n = 5), no treatment; subjects in group G2 (n = 5) were treated with HC; and capacitive RF was applied to the back of each subject in G3 (n = 5) and RF associated with HC in G4 (n = 5). Biopsies were taken 30 days after treatment and then were histologically processed and studied for inflammatory cell counting, collagen content, and morphometry. In addition, FGF2, CD105, and COX-2 expression was assessed by immunohistochemical staining. The most relevant changes were the increase in cellularity and accumulation of intercellular substance in RF-treated animals (G3 and G4). The greatest dermis thickness rate was observed in G4, followed by G3 and G2 (p < 0.05). RF-treated skins (G3 and G4) exhibited a significant overexpression of FGF2 (p < 0.0001) and increased microvessel density (p < 0.0001) in comparison with G1 and G2. Moreover, the amount of COX-2 was significantly higher (p < 0.0001) in dermis of RF-treated areas compared to G1 and G2, and demonstrated differences in G3 (RF) compared to G4 (RF + HC) (p < 0.0001). Our results suggests that RF treatment associated or not with HC induces FGF2 overexpression, promotes neoangiogenesis and modulates the COX-2 expression, subsequently promotes neocollagenesis, and increased thickness rate of dermis.
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