ArticleParasites & vectors2017
Assessing the anthelmintic activity of pyrazole-5-carboxamide derivatives against Haemonchus contortus.
Article in Parasites & vectors, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Evaluation of Serum Supplementation on the Development ofInternational journal of molecular sciences · 2025Article
- A phenotypic screen of the Global Health Priority Box identifies an insecticide with anthelmintic activity.Parasites & vectors · 2024Article
- Survey, Detection, Characterization of Papaya Ringspot Virus from Southern India and Management of Papaya Ringspot Disease.Pathogens (Basel, Switzerland) · 2023Article
- Sensitivity of Haemonchus contortus to anthelmintics using different in vitro screening assays: a comparative study.Parasites & vectors · 2022Article
- A High-Throughput Phenotypic Screen of the 'Pandemic Response Box' Identifies a Quinoline Derivative with Significant Anthelmintic Activity.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Biological Activities Related to Plant Protection and Environmental Effects of Coumarin Derivatives: QSAR and Molecular Docking Studies.International journal of molecular sciences · 2021Article
- Automated phenotyping of mosquito larvae enables high-throughput screening for novel larvicides and offers potential for smartphone-based detection of larval insecticide resistance.PLoS neglected tropical diseases · 2021Article
- Synthesis and anthelmintic activity of benzopyrano[2,3-c]pyrazol-4(2H)-one derivatives.Molecular diversity · 2020Article
- Anthelmintic drug discovery: target identification, screening methods and the role of open science.Beilstein journal of organic chemistry · 2020Review
- Phenotypic screening of the 'Kurz-box' of chemicals identifies two compounds (BLK127 and HBK4) with anthelmintic activity in vitro against parasitic larval stages of Haemonchus contortus.Parasites & vectors · 2019Article
- Selected α-pyrones from the plants Cryptocarya novoguineensis (Lauraceae) and Piper methysticum (Piperaceae) with activity against Haemonchus contortus in vitro.International journal for parasitology. Drugs and drug resistance · 2019Article
- Tetrahydroquinoxalines induce a lethal evisceration phenotype in Haemonchus contortus in vitro.International journal for parasitology. Drugs and drug resistance · 2019Article
- Arylpyrrole and fipronil analogues that inhibit the motility and/or development of Haemonchus contortus in vitro.International journal for parasitology. Drugs and drug resistance · 2018Article
Corrections and comments
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Authors and funding
18 authors at 6 institutions in 3 countries.
Funding
Abstract
backgroundIn this study, we tested five series of pyrazole-5-carboxamide compounds (n = 55) for activity against parasitic stages of the nematode Haemonchus contortus (barber's pole worm), one of the most pathogenic parasites of ruminants.
methodsIn an optimised, whole-organism screening assay, using exsheathed third-stage (xL3) and fourth-stage (L4) larvae, we measured the inhibition of larval motility and development of H. contortus.
resultsAmongst the 55 compounds, we identified two compounds (designated a-15 and a-17) that reproducibly inhibit xL3 motility as well as L4 motility and development, with IC
conclusionsThe present findings provide a sound basis for future work, aimed at identifying the targets of compounds a-15 and a-17 and establishing the modes of action of these chemicals in H. contortus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.