Trial reportJournal of veterinary internal medicine2017
Effect of Dexamethasone and Fluticasone on Airway Hyperresponsiveness in Horses With Inflammatory Airway Disease.
Trial report in Journal of veterinary internal medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Inhaled Corticosteroids Influence Pulmonary Microbiota in Severe Equine Asthma.Animals : an open access journal from MDPI · 2026Article
- Review
- Glucocorticoid treatment in horses with asthma: A narrative review.Journal of veterinary internal medicine · 2021Review
- Treatment of naturally occurring asthma with inhaled fluticasone or oral prednisolone: A randomized pilot trial.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2021Article
- Cigarette Smoke Extract Stimulates MMP-2 Production in Nasal Fibroblasts via ROS/PI3K, Akt, and NF-κB Signaling Pathways.Antioxidants (Basel, Switzerland) · 2020Article
- Efficacy of dexamethasone, salbutamol, and reduced respirable particulate concentration on aerobic capacity in horses with smoke-induced mild asthma.Journal of veterinary internal medicine · 2020Article
- Comparison of Flowmetric Plethysmography and Forced Oscillatory Mechanics to Measure Airway Hyperresponsiveness in Horses.Frontiers in veterinary science · 2020Article
- Effects of nebulized dexamethasone on the respiratory microbiota and mycobiota and relative equine herpesvirus-1, 2, 4, 5 in an equine model of asthma.Journal of veterinary internal medicine · 2020Article
- Effect of injected dexamethasone on relative cytokine mRNA expression in bronchoalveolar lavage fluid in horses with mild asthma.BMC veterinary research · 2019Article
- Effect of different doses of inhaled ciclesonide on lung function, clinical signs related to airflow limitation and serum cortisol levels in horses with experimentally induced mild to severe airway obstruction.Equine veterinary journal · 2019Article
- Adherence to treatment recommendations and short-term outcome of pleasure and sport horses with equine asthma.The Canadian veterinary journal = La revue veterinaire canadienne · 2018Article
- Equine asthma: Integrative biologic relevance of a recently proposed nomenclature.Journal of veterinary internal medicine · 2018Review
- Modeling asthma: Pitfalls, promises, and the road ahead.Journal of leukocyte biology · 2018Review
- Alkaloids fromMolecules (Basel, Switzerland) · 2018Article
- Upper and lower respiratory tract microbiota in horses: bacterial communities associated with health and mild asthma (inflammatory airway disease) and effects of dexamethasone.BMC microbiology · 2017Article
- Redox Biomarker Variations With Severity of Asthma in Horses Across Different Sample Types.Journal of veterinary internal medicineArticle
- Use of inhaled ciclesonide for treatment of moderate asthma in Thoroughbred racehorses.Journal of veterinary internal medicineArticle
- Inflammatory Airway Disease of Horses--Revised Consensus Statement.Journal of veterinary internal medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAirway hyperresponsiveness (AWHR), expressed as hypersensitivity (PC
objectivesTo determine whether dexamethasone (DEX) (0.05 mg/kg IM q24h) and inhaled fluticasone (FLUT) (3,000 μg q12h) administered by inhalation are effective in decreasing AWHR, lung inflammation, and clinical signs in horses with IAD.
methodsA randomized crossover study design was used. Eight horses with IAD were assigned to a treatment group with either DEX or FLUT. Measured outcomes included lung mechanics during bronchoprovocative challenges, bronchoalveolar lavage fluid (BALF) cytology, and scoring of clinical signs during exercise.
resultsDexamethasone and FLUT abolished the increase in R CONCLUSIONS AND CLINICAL IMPORTANCE: Both DEX and FLUT treatments significantly inhibit airway hypersensitivity and hyperreactivity in horses with IAD. There are no significant effects on the clinical signs or the number of inflammatory cells (except lymphocytes) in BALF. The treatments have no residual effect 3 weeks after discontinuation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.