Evidence map›Paper›PMID 28567704›Full record

ArticleMolecular genetics and genomics : MGG2017

Fission yeast Ctf1, a cleavage and polyadenylation factor subunit is required for the maintenance of genomic integrity.

Amit Sonkar, Sachin Gaurav, Shakil Ahmed

Abstract read
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In one paragraph

Article in Molecular genetics and genomics : MGG, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Amit SonkarMolecular and Structural Biology Division, CSIR, Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow, 226031, India.
Sachin GauravMolecular and Structural Biology Division, CSIR, Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow, 226031, India.
Shakil AhmedMolecular and Structural Biology Division, CSIR, Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow, 226031, India. shakil_ahmed@cdri.res.in.ORCID http://orcid.org/0000-0002-5941-3534
Central Drug Research Institute · IN

Funding

Department of Science and Technology, India GAP0124
6 · The paper itself

Abstract

Accurate segregation of chromosome during mitosis requires the coordinated action of several cell cycle checkpoints that monitor replication of the genome and the attachment of sister chromatids to the mitotic spindle apparatus. Here we have characterized the fission yeast Ctf1, an ortholog of S. cerevisiae Rna15 in the maintenance of genomic integrity. The ctf1 is nonessential for the cell survival and its deletion strain exhibit cold sensitivity. The ctf1 deleted cells exhibit genetic interaction with spindle checkpoint protein Mad2 and Bub1. The deletion of ctf1 gene affects the chromosomal attachment to the mitotic spindle leading to the accumulation of Bub1-GFP foci. Ctf1 localizes to the nucleus and physically interacts with Rna14, a cleavage and polyadenylation factor.

Indexed as

Chromosome SegregationChromosomes, FungalGene DeletionGene Knockout TechniquesGenome, FungalMad2 ProteinsMitosisM Phase Cell Cycle CheckpointsmRNA Cleavage and Polyadenylation FactorsNFI Transcription FactorsProtein Serine-Threonine KinasesSchizosaccharomycesSchizosaccharomyces pombe ProteinsSpindle ApparatusBub1 protein, S pombeCTF-1 transcription factorMad2 Proteinsmad2 protein, S pombemRNA Cleavage and Polyadenylation FactorsNFI Transcription FactorsProtein Serine-Threonine KinasesRna14 protein, S pombeSchizosaccharomyces pombe ProteinsChromosome integrityCtf1Rna15Spindle checkpointS. pombe

Identifiers

PMID28567704
OpenAlexW2618153292

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.