Evidence map›Paper›PMID 28567562›Full record

ArticleVirus genes2017

Identification and comparative analysis of hepatitis B virus genotype D/E recombinants in Africa.

Ceejay L Boyce, Lilia Ganova-Raeva, Timothy N A Archampong, Margaret Lartey, Kwamena W Sagoe, Adjoa Obo-Akwa, Ernest Kenu, Awewura Kwara, Jason T Blackard

Open access · greenAbstract readComparative Study
In one paragraph

Article in Virus genes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
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  3. Review
  4. Article
  5. Article
  6. Article
  7. Viruses · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Ceejay L BoyceDivision of Digestive Disease, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Lilia Ganova-RaevaDivision of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Timothy N A ArchampongDepartment of Medicine and Therapeutics, School of Medicine and Dentistry, College of Health Sciences, University of Ghana, Accra, Ghana.
Margaret LarteyDepartment of Medicine and Therapeutics, School of Medicine and Dentistry, College of Health Sciences, University of Ghana, Accra, Ghana.
Kwamena W SagoeDepartment of Medical Microbiology, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, Accra, Ghana.
Adjoa Obo-AkwaDepartment of Medicine and Therapeutics, School of Medicine and Dentistry, College of Health Sciences, University of Ghana, Accra, Ghana.
Ernest KenuKorle-Bu Teaching Hospital, Accra, Ghana.
Awewura KwaraWarren Alpert Medical School of Brown University, Providence, RI, USA.
Jason T BlackardDivision of Digestive Disease, University of Cincinnati College of Medicine, Cincinnati, OH, USA. jason.blackard@uc.edu.ORCID http://orcid.org/0000-0003-2876-3811
University of Ghana · GHUniversity of Cincinnati Medical Center · USCenters for Disease Control and Prevention · USProvidence College · US

Funding

Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI LARRY K BROWN · 1998 to 2026
$51.7M
REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI YADAV, JAGJIT S · 1992 to 2022
$35.4M
Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Alexander Miethke · 2007 to 2026
$24.4M
Miriam/Brown/Tufts Fogarty AIDS International Training and Research ProgramD43TW000237 · FIC · MIRIAM HOSPITAL · PI CU-UVIN, SUSAN · 1993 to 2014
$10.6M
Training Program in Tuberculosis and HIV Research in GhanaD43TW010055 · FIC · UNIVERSITY OF FLORIDA · PI KWARA, AWEWURA JACOB · 2015 to 2019
$1.5M
FIC NIH HHS D43 TW000237FIC NIH HHS D43 TW010055Intramural CDC HHS CC999999NIAID NIH HHS P30 AI042853NIDDK NIH HHS P30 DK078392NIEHS NIH HHS P30 ES006096
6 · The paper itself

Abstract

Globally, there are approximately 240 million people chronically infected with hepatitis B virus (HBV)-a major cause of hepatocellular carcinoma. Ten different HBV genotypes (A-J) have been identified with distinct geographic distributions. Novel variants generated by recombination between different HBV genotypes have been documented worldwide and represent an important element of genetic variability with possible clinical implications. Here, the complete genome sequence of an HBV genotype D/E recombinant from Ghana is reported. The full-length sequence was obtained using rolling circle amplification followed by PCR and sequenced using next-generation sequencing (NGS). A consensus sequence was extracted from the NGS data and underwent phylogenetic analysis to determine genotype, as well as the recombination pattern. Subsequently, the sequence was compared to recombinants described previously in Africa. Based on MCMC phylogenetic analysis, SimPlot recombination analyses, and intragroup genetic distance, the isolate 007N full-length genome is unique compared to other reported D/E recombinants in Africa.

Indexed as

Recombination, GeneticAfricaGenome, ViralGenotypeHepatitis BHepatitis B virusHumansPhylogenyAfricaGenotypesGhanaHepatitis B virusRecombinant/recombinationSubgenotypes

Identifiers

PMID28567562
PMCPMC5710801
OpenAlexW2617174627

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.