Evidence map›Paper›PMID 28567548›Full record

ArticleEuropean radiology2017

The impact of image reconstruction settings on 18F-FDG PET radiomic features: multi-scanner phantom and patient studies.

Isaac Shiri, Arman Rahmim, Pardis Ghaffarian, Parham Geramifar, Hamid Abdollahi, Ahmad Bitarafan-Rajabi

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Article in European radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

110 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Guideline
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  19. Robust vs. Non-robust radiomic features: the quest for optimal machine learning models using phantom and clinical studies.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025
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  20. The Predictive Role of BaselineDiagnostics (Basel, Switzerland) · 2025
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50 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Isaac ShiriDepartment of Medical Physics, School of Medicine, Iran University of Medical Sciences, Junction of Shahid Hemmat and Shahid Chamran Expressways, Tehran, Iran.
Arman RahmimDepartment of Radiology, Johns Hopkins University, Baltimore, MD, 21287, USA.
Pardis GhaffarianChronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Parham GeramifarResearch Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Hamid AbdollahiDepartment of Medical Physics, School of Medicine, Iran University of Medical Sciences, Junction of Shahid Hemmat and Shahid Chamran Expressways, Tehran, Iran. Hamid_rbp@yahoo.com.
Ahmad Bitarafan-RajabiDepartment of Medical Physics, School of Medicine, Iran University of Medical Sciences, Junction of Shahid Hemmat and Shahid Chamran Expressways, Tehran, Iran. bitarafan@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe purpose of this study was to investigate the robustness of different PET/CT image radiomic features over a wide range of different reconstruction settings.

methodsPhantom and patient studies were conducted, including two PET/CT scanners. Different reconstruction algorithms and parameters including number of sub-iterations, number of subsets, full width at half maximum (FWHM) of Gaussian filter, scan time per bed position and matrix size were studied. Lesions were delineated and one hundred radiomic features were extracted. All radiomics features were categorized based on coefficient of variation (COV).

resultsForty seven percent features showed COV ≤ 5% and 10% of which showed COV > 20%. All geometry based, 44% and 41% of intensity based and texture based features were found as robust respectively. In regard to matrix size, 56% and 6% of all features were found non-robust (COV > 20%) and robust (COV ≤ 5%) respectively.

conclusionsVariability and robustness of PET/CT image radiomics in advanced reconstruction settings is feature-dependent, and different settings have different effects on different features. Radiomic features with low COV can be considered as good candidates for reproducible tumour quantification in multi-center studies. KEY POINTS: • PET/CT image radiomics is a quantitative approach assessing different aspects of tumour uptake. • Radiomic features robustness is an important issue over different image reconstruction settings. • Variability and robustness of PET/CT image radiomics in advanced reconstruction settings is feature-dependent. • Robust radiomic features can be considered as good candidates for tumour quantification.

Indexed as

Fluorodeoxyglucose F18Phantoms, ImagingAdultAgedAlgorithmsFemaleHead and Neck NeoplasmsHumansImage Processing, Computer-AssistedLiver NeoplasmsMaleMiddle AgedPositron Emission Tomography Computed TomographyRadiopharmaceuticalsFluorodeoxyglucose F18RadiopharmaceuticalsPET/CTQuantificationRadiomicsReconstruction settingsRobustness

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.