ArticleBreast cancer research and treatment2017
Host genetic modifiers of nonproductive angiogenesis inhibit breast cancer.
Article in Breast cancer research and treatment, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
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- Chronic stress promotes an immunologic inflammatory state and head and neck cancer growth in a humanized murine model.Head & neck · 2022Article
- Induced mammary cancer in rat models: pathogenesis, genetics, and relevance to female breast cancer.Journal of mammary gland biology and neoplasia · 2022Review
- Heritable modifiers of the tumor microenvironment influence nanoparticle uptake, distribution and response to photothermal therapy.Theranostics · 2020Article
- Differences in Expression of Mitochondrial Complexes Due to Genetic Variants May Alter Sensitivity to Radiation-Induced Cardiac Dysfunction.Frontiers in cardiovascular medicine · 2020Article
- Neuronatin is a modifier of estrogen receptor-positive breast cancer incidence and outcome.Breast cancer research and treatment · 2019Article
- Mapping genetic modifiers of radiation-induced cardiotoxicity to rat chromosome 3.American journal of physiology. Heart and circulatory physiology · 2019Article
- Article
- Mapping Mammary Tumor Traits in the Rat.Methods in molecular biology (Clifton, N.J.) · 2019Review
- Germline Risk Contribution to Genomic Instability in Multiple Myeloma.Frontiers in genetics · 2019Review
- Genetic Modifiers of the Breast Tumor Microenvironment.Trends in cancer · 2018Review
- Methods for detecting host genetic modifiers of tumor vascular function using dynamic near-infrared fluorescence imaging.Biomedical optics express · 2018Article
Corrections and comments
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Authors and funding
19 authors at 2 institutions in 1 country.
Funding
Abstract
purposeMultiple aspects of the tumor microenvironment (TME) impact breast cancer, yet the genetic modifiers of the TME are largely unknown, including those that modify tumor vascular formation and function.
methodsTo discover host TME modifiers, we developed a system called the Consomic/Congenic Xenograft Model (CXM). In CXM, human breast cancer cells are orthotopically implanted into genetically engineered consomic xenograft host strains that are derived from two parental strains with different susceptibilities to breast cancer. Because the genetic backgrounds of the xenograft host strains differ, whereas the inoculated tumor cells are the same, any phenotypic variation is due to TME-specific modifier(s) on the substituted chromosome (consomic) or subchromosomal region (congenic). Here, we assessed TME modifiers of growth, angiogenesis, and vascular function of tumors implanted in the SS
resultsBreast cancer xenografts implanted in SS.BN3
conclusionsCollectively, these data suggest that host genetic modifier(s) on RNO3 induce nonproductive angiogenesis that inhibits tumor growth through the DLL4 pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.