ArticleBioMed research international2017
Protective Effects of Lemon Juice on Alcohol-Induced Liver Injury in Mice.
Article in BioMed research international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 49 citations in OpenAlex.
- Honey Lemon Alleviates Alcoholic Liver Disease via Multi-Target Synergistic Mechanisms: An Integrated Study of Network Pharmacology, Molecular Docking, and Animal Experiments.Foods (Basel, Switzerland) · 2026Article
- Experimental Evaluation of Dose-Dependent Hepatorenal Toxicity of Traditionally Prepared Arak in Swiss Albino Mice.Journal of nutrition and metabolism · 2025Article
- The Effect of Lemon Juice (Antioxidants (Basel, Switzerland) · 2024Article
- Alcohol spiked with zolpidem and midazolam potentiates inflammation, oxidative stress and organ damage in a mouse model.Forensic toxicology · 2024Article
- Anti-carcinogenic effects and mechanisms of actions ofAmerican journal of cancer research · 2024Article
- Prevention of the Pro-Aggressive Effects of Ethanol-Intoxicated Mice by Schisandrin B.Nutrients · 2023Article
- Exercise Affects the Formation and Recovery of Alcoholic Liver Disease through the IL-6-p47Cells · 2022Article
- Protective Mechanism of Edible Food Plants against Alcoholic Liver Disease with Special Mention to Polyphenolic Compounds.Nutrients · 2021Review
- Food and Nutrition in the Pathogenesis of Liver Damage.Nutrients · 2021Review
- Detection Technologies for Reactive Oxygen Species: Fluorescence and Electrochemical Methods and Their Applications.Biosensors · 2021Review
- Plant-Based Foods and Their Bioactive Compounds on Fatty Liver Disease: Effects, Mechanisms, and Clinical Application.Oxidative medicine and cellular longevity · 2021Review
- The In Vivo Antioxidant and Hepatoprotective Actions of Selected Chinese Teas.Foods (Basel, Switzerland) · 2020Article
- Health Functions and Related Molecular Mechanisms of Tea Components: An Update Review.International journal of molecular sciences · 2019Review
- Chemical profile andToxicology reports · 2019Article
- Gut Microbiota's Relationship with Liver Disease and Role in Hepatoprotection by Dietary Natural Products and Probiotics.Nutrients · 2018Review
- Five-Golden-Flowers Tea: Green Extraction and Hepatoprotective Effect against Oxidative Damage.Molecules (Basel, Switzerland) · 2018Article
- Aqueous Extract of Pepino (Nutrients · 2018Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic excessive alcohol consumption (more than 40-80 g/day for males and more than 20-40 g/day for females) could induce serious liver injury. In this study, effects of lemon juice on chronic alcohol-induced liver injury in mice were evaluated. The serum biochemical profiles and hepatic lipid peroxidation levels, triacylglycerol (TG) contents, antioxidant enzyme activities, and histopathological changes were examined for evaluating the hepatoprotective effects of lemon juice in mice. In addition, the in vitro antioxidant capacities of lemon juice were determined. The results showed that lemon juice significantly inhibited alcohol-induced increase of alanine transaminase (ALT), aspartate transaminase (AST), hepatic TG, and lipid peroxidation levels in a dose-dependent manner. Histopathological changes induced by alcohol were also remarkably improved by lemon juice treatment. These findings suggest that lemon juice has protective effects on alcohol-induced liver injury in mice. The protective effects might be related to the antioxidant capacity of lemon juice because lemon juice showed in vitro antioxidant capacity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.