ReviewFrontiers in bioengineering and biotechnology2017
The Use of Finite Element Analyses to Design and Fabricate Three-Dimensional Scaffolds for Skeletal Tissue Engineering.
Review in Frontiers in bioengineering and biotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Review
- Cell Behavior and Complex Mechanical Properties of 3D Printed Cell-Laden Alginate-Gelatin Macroporous Mesostructures.Macromolecular bioscience · 2025Article
- Mechanobiology in Action: Biomaterials, Devices, and the Cellular Machinery of Force Sensing.Biomolecules · 2025Review
- Computational methods for biofabrication in tissue engineering and regenerative medicine - a literature review.Computational and structural biotechnology journal · 2024Review
- Mechanical and Computational Fluid Dynamic Models for Magnesium-Based Implants.Materials (Basel, Switzerland) · 2024Article
- Predicting the hyperelastic properties of alginate-gelatin hydrogels and 3D bioprinted mesostructures.Scientific reports · 2023Article
- The Porosity Design and Deformation Behavior Analysis of Additively Manufactured Bone Scaffolds through Finite Element Modelling and Mechanical Property Investigations.Journal of functional biomaterials · 2023Article
- Multilayer 3D bioprinting and complex mechanical properties of alginate-gelatin mesostructures.Scientific reports · 2023Article
- Prediction of Bone Healing around Dental Implants in Various Boundary Conditions by Deep Learning Network.International journal of molecular sciences · 2023Article
- A review of bioengineering techniques applied to breast tissue: Mechanical properties, tissue engineering and finite element analysis.Frontiers in bioengineering and biotechnology · 2023Review
- Geometry-Based Computational Fluid Dynamic Model for Predicting the Biological Behavior of Bone Tissue Engineering Scaffolds.Journal of functional biomaterials · 2022Article
- Comparison of CAD and Voxel-Based Modelling Methodologies for the Mechanical Simulation of Extrusion-Based 3D Printed Scaffolds.Materials (Basel, Switzerland) · 2021Article
- Healing Pattern Analysis for Dental Implants Using the Mechano-Regulatory Tissue Differentiation Model.International journal of molecular sciences · 2020Article
- Application of Finite Element Analysis in Oral and Maxillofacial Surgery-A Literature Review.Materials (Basel, Switzerland) · 2020Review
- A Review on Properties of Natural and Synthetic Based Electrospun Fibrous Materials for Bone Tissue Engineering.Membranes · 2018Review
- Bioceramics and bone healing.EFORT open reviews · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Computational modeling has been increasingly applied to the field of tissue engineering and regenerative medicine. Where in early days computational models were used to better understand the biomechanical requirements of targeted tissues to be regenerated, recently, more and more models are formulated to combine such biomechanical requirements with cell fate predictions to aid in the design of functional three-dimensional scaffolds. In this review, we highlight how computational modeling has been used to understand the mechanisms behind tissue formation and can be used for more rational and biomimetic scaffold-based tissue regeneration strategies. With a particular focus on musculoskeletal tissues, we discuss recent models attempting to predict cell activity in relation to specific mechanical and physical stimuli that can be applied to them through porous three-dimensional scaffolds. In doing so, we review the most common scaffold fabrication methods, with a critical view on those technologies that offer better properties to be more easily combined with computational modeling. Finally, we discuss how modeling, and in particular finite element analysis, can be used to optimize the design of scaffolds for skeletal tissue regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.