Evidence map›Paper›PMID 28567199›Full record

ArticleMalawi medical journal : the journal of Medical Association of Malawi2017

Frequent malaria illness episodes in two Malawian patients on antiretroviral therapy soon after stopping cotrimoxazole preventive therapy.

Wongani Js Nyangulu, Edson Mwinjiwa, Titus H Divala, Randy G Mungwira, Osward Nyirenda, Maxwell Kanjala, Gillian Mbambo, Jane Mallewa, Terrie E Taylor, Matthew B Laurens and 2 more

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Malawi medical journal : the journal of Medical Association of Malawi, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Wongani Js NyanguluDignitas International, Zomba, Malawi.
Edson MwinjiwaDignitas International, Zomba, Malawi.
Titus H DivalaBlantyre Malaria Project, College of Medicine, University of Malawi, Blantyre, Malawi.
Randy G MungwiraBlantyre Malaria Project, College of Medicine, University of Malawi, Blantyre, Malawi.
Osward NyirendaBlantyre Malaria Project, College of Medicine, University of Malawi, Blantyre, Malawi.
Maxwell KanjalaBlantyre Malaria Project, College of Medicine, University of Malawi, Blantyre, Malawi.
Gillian MbamboDivision of Malaria Research, Institute for Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Jane MallewaDepartment of Medicine, College of Medicine, University of Malawi, Blantyre, Malawi.
Terrie E TaylorBlantyre Malaria Project, College of Medicine, University of Malawi, Blantyre, Malawi.
Matthew B LaurensDivision of Malaria Research, Institute for Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Miriam K LauferDivision of Malaria Research, Institute for Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Joep J van OosterhoutDignitas International, Zomba, Malawi.
University of Malawi · MWUniversity of Maryland, Baltimore · USDignitas International · MW

Funding

Clinical trial of trimethoprim-sulfamethoxazole or chloroquine in adults on ARTU01AI089342 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI LAUFER, MIRIAM K. · 2011 to 2017
$13.7M
Mentoring in patient-oriented research in global healthK24AI114996 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI LAUFER, MIRIAM K. · 2016 to 2025
$1.6M
NIAID NIH HHS K24 AI114996NIAID NIH HHS U01 AI089342
6 · The paper itself

Abstract

We describe two Malawian adults on successful antiretroviral therapy who experienced frequent malaria episodes after stopping cotrimoxazole prophylaxis. We argue that, in addition to stopping cotrimoxazole, diminished malaria immunity and drug interactions between efavirenz and artemether-lumefantrine may have played a causative role in the recurrent malaria our patients experienced.

Indexed as

AdultAnti-HIV AgentsAntimalarialsAntiretroviral Therapy, Highly ActiveDrug InteractionsFemaleHIV InfectionsHumansMalariaMiddle AgedTrimethoprim, Sulfamethoxazole Drug CombinationAnti-HIV AgentsAntimalarialsTrimethoprim, Sulfamethoxazole Drug Combination

Identifiers

PMID28567199
PMCPMC5442494
OpenAlexW2611198314

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.