ArticleMalawi medical journal : the journal of Medical Association of Malawi2017
Prevalence of antibody to hepatitis B core antigen among hepatitis B surface antigen-negative blood donors in Ilorin, Nigeria: A cross-sectional study.
Article in Malawi medical journal : the journal of Medical Association of Malawi, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Residual transfusion risk of occult hepatitis B transmission associated to genotypes A and E among blood donors in Yaoundé, Cameroon.BMC infectious diseases · 2025Article
- Hepatitis B Serological Immunity and Exposure Among Blood Donors in Southern Croatia: A Cross-Sectional Study.Vaccines · 2025Article
- Seroprevalence of hepatitis B virus markers of infection and immunity among people living in Libreville, Gabon.IJID regions · 2024Article
- Anti-HBs Seroprevalence in Blood Donors from Tyrol, Austria.Vaccines · 2024Article
- Prevalence of antibody to hepatitis B surface antigen among qualified blood donors in Nanjing, China.Human vaccines & immunotherapeutics · 2023Article
- Prevalence of hepatitis B virus core antibodies among blood donors in Nigeria: Implications for blood safety.African journal of laboratory medicine · 2022Article
- Prevalence of Hepatitis B Virus Infection Markers among Patients of the Ibn Sina University Hospital Center (Rabat, Morocco).Intervirology · 2022Article
- Occult Hepatitis B virus infection among HIV negative and positive isolated anti-HBc individuals in eastern Ethiopia.Scientific reports · 2020Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPost-transfusion hepatitis occurs even with stringent donor selection criteria and screening for hepatitis B surface antigen (HBsAg). The objective of this study was to determine the prevalence of antibody to hepatitis B core antigen (anti-HBc) in HBsAg-negative blood donors.
methodsThis was a cross-sectional study in which 200 HBsAg-negative blood donors were recruited. Screening for viral markers was done using both a rapid test kit and enzyme-linked immunosorbent assay (ELISA) for anti-HBc IgM. Quantitative and qualitative analysis of anti-HBc IgM was done by "capture" enzyme immunoassay using DIA.PRO HBc IgM test kits. The other viral markers were investigated using one step cassette style HBV tests. SPSS version 16 was used for data analysis. A P-value of 0.05 or less was considered significant.
resultsThere were 190 male (95%) and 10 female (5%) blood donors, with a mean age of 31.7 ± 7.9 years. The prevalence of anti-HBc IgM was 4%. The other viral markers (HBeAg, anti-HBeAg, anti-HBs and total anti-HBc) had a prevalence of 1.5%, 23%, 2.5%, and 32.5%, respectively.
conclusionsThe prevalence of anti-HBc IgM in this study was high, and this supports the fact that screening blood donors for HBsAg alone is not sufficient to prevent transmission of HBV.
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