ReviewUltrasound (Leeds, England)2017
Neonatal respiratory distress syndrome: Chest X-ray or lung ultrasound? A systematic review.
Review in Ultrasound (Leeds, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 5 syntheses or guidelines pooled it, 118 citations in OpenAlex.
- The role of chest X-ray in the diagnosis of neonatal respiratory distress syndrome: a systematic review concerning low-resource birth scenarios.Global health action · 2024Pooled it
- Pooled it
- Lung Ultrasound for the Diagnosis of Neonatal Respiratory Distress Syndrome: A Meta-analysis.Ultrasound quarterly · 2020Pooled it
- A simplified lung ultrasound for the diagnosis of interstitial lung disease in connective tissue disease: a meta-analysis.Arthritis research & therapy · 2019Pooled it
- [Guideline on lung ultrasound to diagnose pulmonary diseases in newborn infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019Guideline
- Early lung ultrasound at one hour of life and subsequent oxygen requirement during the first 48 h after birth: a prospective observational study.Italian journal of pediatrics · 2026Observational
- Combined diaphragm and lung ultrasound profiling in healthy full-term neonates: a study of early postnatal function.European journal of pediatrics · 2026Observational
- Observational
- Lung Ultrasound in Pediatrics: A Review with Core Principles That Every User Should Know.Diagnostics (Basel, Switzerland) · 2025Review
- Evaluating the efficacy of LDH and inflammatory indices in discriminating neonatal respiratory distress syndrome from transient tachypnea of the newborns.BMC pediatrics · 2025Article
- The diagnostic value and efficacy evaluation of lung ultrasound score in neonatal respiratory distress syndrome: a prospective observational study.Frontiers in pediatrics · 2025Article
- Lung Ultrasound in Neonates: A Narrative Review Along With Diagnostic Insights and Early Postnatal Applications.Cureus · 2024Review
- Review
- Maternal prenatal systemic inflammation indexes predicts premature neonatal respiratory distress syndrome.Scientific reports · 2024Article
- Setting the Standards: Neonatal Lung Ultrasound in Clinical Practice.Diagnostics (Basel, Switzerland) · 2024Review
- RDS-NExT workshop: consensus statements for the use of surfactant in preterm neonates with RDS.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Radiological Imaging in Chest Diseases: Moving Away from Conventional Modes.Indian journal of pediatrics · 2023Review
- Comparison between lung ultrasonography and chest X-ray in the evaluation of neonatal respiratory distress syndrome.Journal of ultrasound · 2023Article
- Lung Ultrasound in the Early Diagnosis and Management of the Mild Form of Meconium Aspiration Syndrome: A Case Report.Diagnostics (Basel, Switzerland) · 2023Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimNeonatal respiratory distress syndrome is a leading cause of morbidity in preterm new-born babies (<37 weeks gestation age). The current diagnostic reference standard includes clinical testing and chest radiography with associated exposure to ionising radiation. The aim of this review was to compare the diagnostic accuracy of lung ultrasound against the reference standard in symptomatic neonates of ≤42 weeks gestation age.
methodsA systematic search of literature published between 1990 and 2016 identified 803 potentially relevant studies. Six studies met the review inclusion criteria and were retrieved for analysis. Quality assessment was performed before data extraction and meta-analysis.
resultsFour prospective cohort studies and two case control studies included 480 neonates. All studies were of moderate methodological quality although heterogeneity was evident across the studies. The pooled sensitivity and specificity of lung ultrasound were 97% (95% confidence interval [CI] 94-99%) and 91% (CI: 86-95%) respectively. False positive diagnoses were made in 16 cases due to pneumonia (n = 8), transient tachypnoea (n = 3), pneumothorax (n = 1) and meconium aspiration syndrome (n = 1); the diagnoses of the remaining three false positive results were not specified. False negatives diagnoses occurred in nine cases, only two were specified as air-leak syndromes.
conclusionsLung ultrasound was highly sensitive for the detection of neonatal respiratory distress syndrome although there is potential to miss co-morbid air-leak syndromes. Further research into lung ultrasound diagnostic accuracy for neonatal air-leak syndrome and economic modelling for service integration is required before lung ultrasound can replace chest radiography as the imaging component of the reference standard.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.