ArticleKorean circulation journal2017
Combined Use of Neutrophil to Lymphocyte Ratio and C-Reactive Protein Level to Predict Clinical Outcomes in Acute Myocardial Infarction Patients Undergoing Percutaneous Coronary Intervention.
Article in Korean circulation journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Evaluation of C-reactive protein as predictor of adverse prognosis in acute myocardial infarction after percutaneous coronary intervention: A systematic review and meta-analysis from 18,715 individuals.Frontiers in cardiovascular medicine · 2022Pooled it
- Efficacy of low-fat milk and yogurt fortified with vitamin DJournal of health, population, and nutrition · 2022Trial
- Association of C-reactive protein to albumin ratio with the risk of left ventricular aneurysm formation.Scientific reports · 2026Article
- CRP Cutoff Value in East Asians With Coronary Heart Disease: A Systematic Review and Meta-Analysis.JACC. Asia · 2026Article
- A composite model incorporating systemic inflammatory burden and GRACE score for enhanced identification of elevated myocardial stress in acute myocardial infarction: an exploratory analysis.Frontiers in cardiovascular medicine · 2026Article
- The novel CKD-INF score for distinguishing infectious from non-infectious inflammation in patients with non-dialysis chronic kidney disease.Scientific reports · 2025Article
- ASSESSING THE PREDICTIVE VALUE OF THE C-REACTIVE PROTEIN AND NEUTROPHIL-TO-LYMPHOCYTE RATIO COMBINED SCORE FOR ORGAN FAILURE IN ACUTE PANCREATITIS.Arquivos de gastroenterologia · 2025Article
- Article
- Prediction of in-hospital mortality risk for patients with acute ST-elevation myocardial infarction after primary PCI based on predictors selected by GRACE score and two feature selection methods.Frontiers in cardiovascular medicine · 2024Article
- Combined use of CRP with neutrophil-to-lymphocyte ratio in differentiating between infectious and noninfectious inflammation in hemodialysis patients.Scientific reports · 2023Article
- Neutrophil-To-Lymphocyte Ratio and Abdominal Aortic Atherosclerosis among Asymptomatic Individuals.Arquivos brasileiros de cardiologia · 2022Article
- [EJNMMI research · 2020Article
- Prognostic value of the combination of GRACE risk score and mean platelet volume to lymphocyte count ratio in patients with ST-segment elevation myocardial infarction after percutaneous coronary intervention.Experimental and therapeutic medicine · 2020Article
- Correlation Between Neutrophil Count and Prognosis in STEMI Patients with Chronic Renal Dysfunction: A Retrospective Cohort Study.Open life sciences · 2019Article
- Inflammation in Cardiovascular Disease.Korean circulation journal · 2017Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesBoth neutrophil to lymphocyte ratio (NLR) and C-reactive protein (CRP) are biomarkers associated with poor prognosis of patients with acute myocardial infarction (AMI). However, the combined usefulness of NLR and CRP in predicting adverse outcomes has not been investigated. SUBJECTS AND
methodsWe analyzed 381 consecutive AMI patients who underwent percutaneous coronary intervention (PCI) from January 2012 to January 2014. The endpoints were all-cause mortality, recurrent myocardial infarction (MI), stent thrombosis, repeat revascularization, stroke, and major adverse cardiac and cerebrovascular events (MACCE) at 2-year follow-up. Included patients were divided into 4 groups according to the optimal cut-off values for NLR and CRP on receiver operating characteristic analysis predicting mortality.
resultsPatients with both high NLR (>6.30) and high CRP (>0.76) had significantly greater risk of all-cause death and MACCE at 24 months, with no significant increase in the risk of recurrent MI, stent thrombosis, or stroke compared with patients with either low NLR or low CRP, as well as those with low NLR and low CRP. Kaplan-Meier analysis revealed significantly lower survival in patients with high NLR-CRP. On Cox multivariate analysis, high NLR-CRP (hazard ratio 23.172, 95% confidence interval 6.575 to 81.671, p<0.001) was an independent predictor of all-cause death.
conclusionElevated levels of both NLR and CRP are associated with increased risk of long-term mortality in AMI patients who have undergone PCI.
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