ReviewContemporary clinical dentistry
Prevention and Treatment of White Spot Lesions in Orthodontic Patients.
Review in Contemporary clinical dentistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04827966 (A Randomized Controlled Trial on the Remineralization Agents Used for the Treatment of White Spot Lesions), which is not on this map. Cited by 88 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Controlled Trial on the Remineralization Agents Used for the Treatment of White Spot Lesions
Who cites it
88 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- White spot lesion in self-ligating versus conventional ligating bracket systems: A systematic review.The Journal of international medical research · 2025Pooled it
- Remineralization and anti-demineralization effect of orthodontic adhesives on enamel surrounding orthodontic brackets: a systematic review of in vitro studies.BMC oral health · 2024Pooled it
- The effect of the Er,Cr:YSGG laser combined casein phosphopeptide amorphous calcium phosphate for enamel remineralisation: a systematic review and meta-analysis of in vitro studies.Lasers in medical science · 2023Pooled it
- Shear bond strength after using sealant before bonding: a systematic review and meta-analysis of in vitro studies.Clinical oral investigations · 2022Pooled it
- The Effect of Bioactive Glass-Enhanced Orthodontic Bonding Resins on Prevention of Demineralization: A Systematic Review.Molecules (Basel, Switzerland) · 2020Pooled it
- Resin infiltration versus fluoride varnish for visual improvement of white spot lesions during multibracket treatment. A randomized-controlled clinical trial.Clinical oral investigations · 2024Trial
- The efficacy of the dental Water Jet, orthodontic, and conventional toothbrushes in plaque removal around orthodontic braces in adolescents: A randomized controlled trial.Clinical and experimental dental research · 2023Trial
- Morphological Characteristics and Prevention of Tooth Enamel Demineralization during Orthodontic Treatment with Non-Removable Appliances.International journal of environmental research and public health · 2022Trial
- Biofilm formation following chitosan-based varnish or chlorhexidine-fluoride varnish application in patients undergoing fixed orthodontic treatment: a double blinded randomised controlled trial.BMC oral health · 2021Trial
- Do total or partial etching procedures effect the rate of white spot lesion formation? A single-center, randomized, controlled clinical trial.The Angle orthodontist · 2019Trial
- Tooth color change due to different etching and debonding procedures.The Angle orthodontist · 2018Trial
- Awareness and perception of white spot lesions amongst adolescents undergoing orthodontic treatment with fixed appliances: a cross-sectional study of caries preventive adherence.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Article
- Comparison of the effect of self-assembling peptide PBMC oral health · 2026Article
- Evaluation of an orthodontic adhesive containing 2 wt% nano-hydroxyapatite synthesized from a biogenic calcium precursor: antibacterial activity, calcium ion concentration, and enamel demineralization.Biomaterial investigations in dentistry · 2026Article
- The effect of nanohydroxyapatite serum and toothpaste on prevention of enamel demineralization around orthodontic brackets: an in vitro study.BMC oral health · 2025Article
- Assessment of internet data on orthodontic treatment and oral hygiene in the Marmara region using Google Trends:a methodological study.European oral research · 2025Article
- Influence of Bioactive Glass Incorporation in Resin Adhesives of Orthodontic Brackets on Adhesion Properties and Calcium Release.Polymers · 2025Article
- Laser-assisted Icon and clinpro for restoring white spot lesions: an in vitro comparative study.Odontology · 2025Article
- White Spot Lesion Treatment Options: A Systematic Review of Different Techniques for Masking These Lesions.Gels (Basel, Switzerland) · 2025Review
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Decalcification of enamel, appearing as white spot lesions (WSLs), around fixed orthodontic appliances is a major challenge during and after fixed orthodontic treatment by considering the fact that the goal of orthodontic treatment is to enhance facial and dental esthetic appearance. Banded or bonded teeth exhibit a significantly higher rate of WSLs compared to the controls with no braces as fixed appliances and the bonding materials promote retention of biofilms. These lesions are managed in the first step by establishing good oral hygiene habits and prophylaxis with topical fluorides, including high-fluoride toothpastes, fluoride mouthwashes, gels, varnishes, fluoride-containing bonding materials, and elastic ligatures. Recently, other materials and methods have been recommended, including the application of casein phosphopeptides-amorphous calcium phosphate, antiseptics, probiotics, polyols, sealants, laser, tooth bleaching agents, resin infiltration, and microabrasion. This article reviews the currently used methods to manage enamel demineralization during and after orthodontic treatment and the risk factors and preventive measures based on the latest evidence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.