Evidence map›Paper›PMID 28566744›Full record

ArticleScientific reports2017

MRI tracking of autologous pancreatic progenitor-derived insulin-producing cells in monkeys.

Chunlin Zou, Yi Lu, Xiahong Teng, Shuyan Wang, Xiaoting Sun, Fen Huang, Guannan Shu, Xin Huang, Hongwei Guo, Zhiguo Chen and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Chunlin ZouCenter for Translational Medicine, Guangxi Medical University, Guangxi, P.R. China. zouchunlin@sohu.com.
Yi LuCenter for Translational Medicine, Guangxi Medical University, Guangxi, P.R. China.
Xiahong TengCenter for Translational Medicine, Guangxi Medical University, Guangxi, P.R. China.
Shuyan WangCell Therapy Center, Xuanwu Hospital, Capital Medical University, Beijing, P.R. China.
Xiaoting SunCenter for Translational Medicine, Guangxi Medical University, Guangxi, P.R. China.
Fen HuangCenter for Translational Medicine, Guangxi Medical University, Guangxi, P.R. China.
Guannan ShuCenter for Translational Medicine, Guangxi Medical University, Guangxi, P.R. China.
Xin HuangCenter for Translational Medicine, Guangxi Medical University, Guangxi, P.R. China.
Hongwei GuoCenter for Translational Medicine, Guangxi Medical University, Guangxi, P.R. China.
Zhiguo ChenCell Therapy Center, Xuanwu Hospital, Capital Medical University, Beijing, P.R. China.
Jian ZhangCenter for Translational Medicine, Guangxi Medical University, Guangxi, P.R. China.
Yu Alex ZhangCell Therapy Center, Xuanwu Hospital, Capital Medical University, Beijing, P.R. China. yaz@bjsap.org.
Guangxi Medical University · CNCapital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Insulin-producing cells (IPCs) derived from a patient's own stem cells offer great potential for autologous transplantation in diabetic patients. However, the limited survival of engrafted cells remains a bottleneck in the application of this strategy. The present study aimed to investigate whether nanoparticle-based magnetic resonance (MR) tracking can be used to detect the loss of grafted stem cell-derived IPCs in a sensitive and timely manner in a diabetic monkey model. Pancreatic progenitor cells (PPCs) were isolated from diabetic monkeys and labeled with superparamagnetic iron oxide nanoparticles (SPIONs). The SPION-labeled cells presented as hypointense signals on MR imaging (MRI). The labeling procedure did not affect the viability or IPC differentiation of PPCs. Importantly, the total area of the hypointense signal caused by SPION-labeled IPCs on liver MRI decreased before the decline in C-peptide levels after autotransplantation. Histological analysis revealed no detectable immune response to the grafts and many surviving insulin- and Prussian blue-positive cell clusters on liver sections at one year post-transplantation. Collectively, this study demonstrates that SPIO nanoparticles can be used to label stem cells for noninvasive, sensitive, longitudinal monitoring of stem cell-derived IPCs in large animal models using a conventional MR imager.

Indexed as

Magnetic Resonance ImagingAnimalsCell DifferentiationCell TrackingContrast MediaC-PeptideDiabetes Mellitus, Type 1Disease Models, AnimalFerric CompoundsHumansMacaca fascicularisMagnetite NanoparticlesMesenchymal Stem Cell TransplantationPancreatic Polypeptide-Secreting CellsTransplantation, AutologousContrast MediaC-PeptideFerric Compoundsferric oxideMagnetite Nanoparticles

Identifiers

PMID28566744
PMCPMC5451407
OpenAlexW2617618077

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.