ArticleScientific reports2017
Endometriosis foci differentiation by rapid lipid profiling using tissue spray ionization and high resolution mass spectrometry.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Metabolome analysis as a potential source of endometriosis biomarkers with the use of multiomics approach in its diagnosis.Scientific reports · 2025Article
- Mass spectrometry imaging reveals alterations in protein and N-glycan molecular signatures in endometriosis tissues.Analytical and bioanalytical chemistry · 2025Article
- The strategic role of lipidomics in biomarker identification and diagnosis of gynecological diseases.Frontiers in endocrinology · 2025Review
- Metabolomics for the identification of biomarkers in endometriosis.Archives of gynecology and obstetrics · 2024Review
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- Article
- Alterations in lipid profile upon uterine fibroids and its recurrence.Scientific reports · 2021Article
- Lipidomic Alterations and PPAROxidative medicine and cellular longevity · 2021Article
- [Research progress on biomarkers for endometriosis based on lipidomics].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2020Article
- Metabolomics for Diagnosis and Prognosis of Uterine Diseases? A Systematic Review.Journal of personalized medicine · 2020Review
- Validation of Breast Cancer Margins by Tissue Spray Mass Spectrometry.International journal of molecular sciences · 2020Article
- Applications of Mass Spectrometry for Clinical Diagnostics: The Influence of Turnaround Time.Analytical chemistry · 2020Review
- Molecular Imaging of Endometriosis Tissues using Desorption Electrospray Ionization Mass Spectrometry.Scientific reports · 2019Article
- Identification of potential endometriosis biomarkers in peritoneal fluid and blood plasma via shotgun lipidomics.Clinical mass spectrometry (Del Mar, Calif.) · 2019Article
- Discovery of Phosphatidic Acid, Phosphatidylcholine, and Phosphatidylserine as Biomarkers for Early Diagnosis of Endometriosis.Frontiers in physiology · 2018Article
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obtaining fast screening information on molecular composition of a tissue sample is of great importance for a disease biomarkers search and for online surgery control. In this study, high resolution mass spectrometry analysis of eutopic and ectopic endometrium tissues (90 samples) is done using direct tissue spray mass spectrometry in both positive and negative ion modes. The most abundant peaks in the both ion modes are those corresponding to lipids. Species of three lipid classes are observed, phosphatidylcholines (PC), sphingomyelins (SM) and phosphoethanolamines (PE). Direct tissue analysis gives mainly information on PC and SM lipids (29 species) in positive ion mode and PC, SM and PE lipids (50 species) in negative ion mode which gives complementary data for endometriosis foci differentiation. The biggest differences were found for phospholipids with polyunsaturated acyls and alkils. Although, tissue spray shows itself as appropriate tool for tissue investigation, caution should be paid to the interpretation of mass spectra because of their higher complexity with more possible adducts formation and multiple interferences must be taken into account. The present work extends the application of direct tissue analysis for the rapid differentiation between endometriotic tissues of different foci.
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