ArticleScientific reports2017
Potent anti-cancer effects of less polar Curcumin analogues on gastric adenocarcinoma and esophageal squamous cell carcinoma cells.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 52 citations in OpenAlex.
- Synthetic Curcumin Analogs in the Treatment of Cancer: A Literature Review.Current medicinal chemistry · 2025Review
- Design and synthesis of a novel curcumin-combretastatin A4 molecular skeleton: two pharmacophores.RSC advances · 2024Article
- The ameliorative effects of curcumin nanomicelle on testicular damage in the mouse model of multiple sclerosis.BMC complementary medicine and therapies · 2024Article
- Identifying natural products for gastric cancer treatment through pharmacophore creation, 3D QSAR, virtual screening, and molecular dynamics studies.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2023Article
- Curcumin a Natural Phenol and Its Therapeutic Role in Cancer and Photodynamic Therapy: A Review.Pharmaceutics · 2023Review
- Beta-catenin knockdown impairs the viability of ovarian cancer cells by modulating YAP-dependent glycolysis.American journal of translational research · 2023Article
- The effect of curcumin on hypoxia in the tumour microenvironment as a regulatory factor in cancer.Archives of medical science : AMS · 2023Article
- Curcumin Modulates Oxidative Stress, Fibrosis, and Apoptosis in Drug-Resistant Cancer Cell Lines.Life (Basel, Switzerland) · 2022Article
- Combination Anticancer Therapies Using Selected Phytochemicals.Molecules (Basel, Switzerland) · 2022Review
- Curcumin's prevention of inflammation-driven early gastric cancer and its molecular mechanism.Chinese herbal medicines · 2022Review
- The anticancer effects of curcumin and clinical research progress on its effects on esophageal cancer.Frontiers in pharmacology · 2022Review
- Article
- A Systematic Review of the Mechanisms Underlying Treatment of Gastric Precancerous Lesions by Traditional Chinese Medicine.Evidence-based complementary and alternative medicine : eCAM · 2020Review
- A Review of Curcumin and Its Derivatives as Anticancer Agents.International journal of molecular sciences · 2019Review
- Oral curcumin for radiation dermatitis: a URCC NCORP study of 686 breast cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018Article
- Effects of a polyherbal formulation on the quality of life and survival of patients with common upper gastrointestinal cancers: A randomized placebo-controlled trial.Avicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Curcumin and its chalcone derivatives inhibit the growth of human cancer cells. It is reported that replacement of two OH groups in curcumin with less polar groups like methoxy increases its anti-proliferative activity. In this study, we explored benzylidine cyclohexanone derivatives with non-polar groups, to see if they possess increased anti-cancer activity. Novel 2,6-bis benzylidine cyclohexanone analogues of curcumin were synthesized, and their inhibitory effects on gastric adenocarcinoma (AGS) and esophageal squamous cell carcinoma (KYSE30) cancer cells were studied using an MTT assay. Cell apoptosis was detected by EB/AO staining, and cell cycle was analyzed by flow cytometry. Real-time PCR was performed for gene expression analysis. All synthesized analogues were cytotoxic toward gastric and esophageal cancer cells and showed lower IC
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