ArticleScientific reports2017
Photoacoustic imaging of voltage responses beyond the optical diffusion limit.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 61 citations in OpenAlex.
- Material-based neuroimaging and biomarker detection for central nervous system disorder.Materials today. Bio · 2025Review
- Clinical translation of photoacoustic imaging using exogenous molecular contrast agents [Invited].Biomedical optics express · 2025Review
- Enhanced dual-mode imaging: Superior photoacoustic and ultrasound endoscopy in live pigs using a transparent ultrasound transducer.Science advances · 2024Article
- Neurophotonic methods in approach to in vivo animal epileptic models: Advantages and limitations.Epilepsia · 2024Review
- The sound of blood: photoacoustic imaging in blood analysis.Medicine in novel technology and devices · 2023Article
- High-contrast spectroscopic photoacoustic characterization of thermal tissue ablation in the visible spectrum.Ultrasonography (Seoul, Korea) · 2023Article
- Tools to measure membrane potential of neurons.Biomedical journal · 2022Review
- Multiscale photoacoustic tomography of neural activities with GCaMP calcium indicators.Journal of biomedical optics · 2022Article
- Looking deep inside tissue with photoacoustic molecular probes: a review.Journal of biomedical optics · 2022Review
- Neurophotonic tools for microscopic measurements and manipulation: status report.Neurophotonics · 2022Article
- Multiscale Photoacoustic Tomography of a Genetically Encoded Near-Infrared FRET Biosensor.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Dual-model wearable photoacoustic microscopy and electroencephalograph: study of neurovascular coupling in anesthetized and freely moving rats.Biomedical optics express · 2021Article
- Fluorescence/photoacoustic imaging-guided nanomaterials for highly efficient cancer theragnostic agent.Scientific reports · 2021Article
- 3D Monte Carlo simulation of light distribution in mouse brain in quantitative photoacoustic computed tomography.Quantitative imaging in medicine and surgery · 2021Article
- Functional photoacoustic calcium imaging using chlorophosphonazo III in a 3D tumor cell culture.Biomedical optics express · 2021Article
- Photoacoustic Neuroimaging - Perspectives on a Maturing Imaging Technique and its Applications in Neuroscience.Frontiers in neuroscience · 2021Review
- Optimization of Near-Infrared Fluorescence Voltage-Sensitive Dye Imaging for Neuronal Activity Monitoring in the Rodent Brain.Frontiers in neuroscience · 2021Article
- A Systematic Review of Cerebral Functional Near-Infrared Spectroscopy in Chronic Neurological Diseases-Actual Applications and Future Perspectives.Diagnostics (Basel, Switzerland) · 2020Review
- Chemical Targeting of Voltage Sensitive Dyes to Specific Cells and Molecules in the Brain.Journal of the American Chemical Society · 2020Article
- Transcranial photoacoustic imaging of NMDA-evoked focal circuit dynamics in the rat hippocampus.Journal of neural engineering · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Non-invasive optical imaging of neuronal voltage response signals in live brains is constrained in depth by the optical diffusion limit, which is due primarily to optical scattering by brain tissues. Although photoacoustic tomography breaks this limit by exciting the targets with diffused photons and detecting the resulting acoustic responses, it has not been demonstrated as a modality for imaging voltage responses. In this communication, we report the first demonstration of photoacoustic voltage response imaging in both in vitro HEK-293 cell cultures and in vivo mouse brain surfaces. Using spectroscopic photoacoustic tomography at isosbestic wavelengths, we can separate voltage response signals and hemodynamic signals on live brain surfaces. By imaging HEK-293 cell clusters through 4.5 mm thick ex vivo rat brain tissue, we demonstrate photoacoustic tomography of cell membrane voltage responses beyond the optical diffusion limit. Although the current voltage dye does not immediately allow in vivo deep brain voltage response imaging, we believe our method opens up a feasible technical path for deep brain studies in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.