ArticleScientific reports2017
Quantitative refractive index distribution of single cell by combining phase-shifting interferometry and AFM imaging.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 104 citations in OpenAlex.
- Speckle-based measurement of the fractional azimuthal index of orbital angular momentum beams for refractive index sensing.Nature communications · 2026Article
- Three-dimensional forward-scattering imaging flow cytometry system for single-cell analysis.APL photonics · 2025Article
- Liquid-Liquid Phase Separation from the Viewpoint of Molecular Crowding Environment: A Raman Imaging Study.The journal of physical chemistry. B · 2025Review
- Measuring the effect of repetitive stretching on the deformability of human red blood cells using optical tweezers.Scientific reports · 2025Article
- Organic electro-scattering antenna: Wireless and multisite probing of electrical potentials with high spatial resolution.Science advances · 2024Article
- Evaluation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using a high figure-of-merit plasmonic multimode refractive index optical sensor.Scientific reports · 2024Article
- Single-cell laser emitting cytometry for label-free nucleolus fingerprinting.Nature communications · 2024Article
- Deformable microlaser force sensing.Light, science & applications · 2024Article
- Holotomography and atomic force microscopy: a powerful combination to enhance cancer, microbiology and nanotoxicology research.Discover nano · 2024Review
- Real-time simultaneous refractive index and thickness mapping of sub-cellular biology at the diffraction limit.Communications biology · 2024Article
- Quantitative Measurements of Red Blood Cell Indices Using Spectroscopic Differential Phase-Contrast Microscopy.Chemical & biomedical imaging · 2023Article
- Quantitative fluorescence emission anisotropy microscopy for implementing homo-fluorescence resonance energy transfer measurements in living cells.Molecular biology of the cell · 2023Article
- A low-cost, label-free microfluidic scanning flow cytometer for high-accuracy quantification of size and refractive index of particles.Lab on a chip · 2023Article
- Measurement of tissue optical properties in a wide spectral range: a review [Invited].Biomedical optics express · 2023Review
- Quantitative phase velocimetry measures bulk intracellular transport of cell mass during the cell cycle.Scientific reports · 2022Article
- Dual-modality digital holographic and polarization microscope to quantify phase and birefringence signals in biospecimens with a complex microstructure.Biomedical optics express · 2022Article
- Sensitive Detection of SARS-CoV-2 Using a Novel Plasmonic Fiber Optic Biosensor Design.Plasmonics (Norwell, Mass.) · 2022Article
- Engineered nano-sphere array of gold-DNA core-shells and junctions as opto-plasmonic sensors for biodetection.RSC advances · 2021Article
- Spatial light interference microscopy: principle and applications to biomedicine.Advances in optics and photonics · 2021Article
- Refractive Index Changes of Cells and Cellular Compartments Upon Paraformaldehyde Fixation Acquired by Tomographic Phase Microscopy.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell refractive index, an intrinsic optical parameter, is closely correlated with the intracellular mass and concentration. By combining optical phase-shifting interferometry (PSI) and atomic force microscope (AFM) imaging, we constructed a label free, non-invasive and quantitative refractive index of single cell measurement system, in which the accurate phase map of single cell was retrieved with PSI technique and the cell morphology with nanoscale resolution was achieved with AFM imaging. Based on the proposed AFM/PSI system, we achieved quantitative refractive index distributions of single red blood cell and Jurkat cell, respectively. Further, the quantitative change of refractive index distribution during Daunorubicin (DNR)-induced Jurkat cell apoptosis was presented, and then the content changes of intracellular biochemical components were achieved. Importantly, these results were consistent with Raman spectral analysis, indicating that the proposed PSI/AFM based refractive index system is likely to become a useful tool for intracellular biochemical components analysis measurement, and this will facilitate its application for revealing cell structure and pathological state from a new perspective.
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