Evidence map›Paper›PMID 28566554›Full record

ArticleMolecular biology of the cell2017

PI3K class II α regulates δ-opioid receptor export from the

Daniel J Shiwarski, Marlena Darr, Cheryl A Telmer, Marcel P Bruchez, Manojkumar A Puthenveedu

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
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  4. GPCR signaling via cAMP nanodomains.The Biochemical journal · 2025
    Review
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  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Human C1orf27 protein interacts with αThe Journal of biological chemistry · 2022
    Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Peripherally Acting Opioids in Orofacial Pain.Frontiers in neuroscience · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Daniel J ShiwarskiDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213.
Marlena DarrDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213.
Cheryl A TelmerDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213.
Marcel P BruchezDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213.
Manojkumar A PuthenveeduDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213 map3@andrew.cmu.edu.
Carnegie Mellon University · USCenter for the Neural Basis of Cognition · USImaging Center · US

Funding

Fluorescent Biosensors for Networks and PathwaysU54GM103529 · NIGMS · CARNEGIE-MELLON UNIVERSITY · PI WAGGONER, ALAN S. · 2012 to 2013
$6.3M
MECHANISMS ENSURING SEQUENCE-DEPENDENT GPCR RECYCLINGR01GM117425 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PUTHENVEEDU, MANOJKUMAR A · 2016 to 2020
$1.5M
Regulation of Clathrin-Coated Pits by the Mu-Opioid ReceptorR00DA024698 · NIDA · CARNEGIE-MELLON UNIVERSITY · PI PUTHENVEEDU, MANOJKUMAR A · 2009 to 2011
$735k
TRAFFICKING AND FUNCTION OF MU-OPIOD RECEPTOR GENETIC VARIANTSR21DA036086 · NIDA · CARNEGIE-MELLON UNIVERSITY · PI PUTHENVEEDU, MANOJKUMAR A · 2013 to 2014
$371k
Regulation of Clathrin-Coated Pits by the Mu-Opioid ReceptorK99DA024698 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PUTHENVEEDU, MANOJKUMAR A · 2008 to 2008
$74k
NIDA NIH HHS K99 DA024698NIDA NIH HHS R00 DA024698NIDA NIH HHS R21 DA036086NIGMS NIH HHS R01 GM117425NIGMS NIH HHS U54 GM103529
6 · The paper itself

Abstract

The interplay between signaling and trafficking by G protein-coupled receptors (GPCRs) has focused mainly on endocytic trafficking. Whether and how surface delivery of newly synthesized GPCRs is regulated by extracellular signals is less understood. Here we define a signaling-regulated checkpoint at the

Indexed as

AnimalsCell MembraneCells, CulturedNerve Growth FactorNeuronsPC12 CellsPhosphatidylinositol 3-KinasesPhosphatidylinositolsPhosphorylationProtein TransportRatsReceptors, Opioid, deltaSignal Transductiontrans-Golgi NetworkNerve Growth FactorPhosphatidylinositol 3-KinasesPhosphatidylinositolsReceptors, Opioid, delta

Identifiers

PMID28566554
PMCPMC5531736
OpenAlexW2618737030

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.