ReviewPhysiological reviews2017
Role of the Immune System in Hypertension.
Review in Physiological reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06764277 (Mechanisms and Phenotypes of Hypertension in Patients in Chronic Hemodialysis), which is not on this map. Cited by 214 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mechanisms and Phenotypes of Hypertension in Patients in Chronic Hemodialysis
Who cites it
214 citing papers in PubMed, 7 syntheses or guidelines pooled it, 380 citations in OpenAlex.
- Characterizing blood pressure trajectories in people living with HIV following antiretroviral therapy: A systematic review.HIV medicine · 2023Pooled it
- Meta-analysis of differences in neutrophil to lymphocyte ratio between hypertensive and non-hypertensive individuals.BMC cardiovascular disorders · 2023Pooled it
- The role of inflammatory biomarkers in the development and progression of pre-eclampsia: a systematic review and meta-analysis.Frontiers in immunology · 2023Pooled it
- Mortality associated with COVID-19 and hypertension in sub-Saharan Africa. A systematic review and meta-analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2022Pooled it
- Determinants of Serum Immunoglobulin Levels: A Systematic Review and Meta-Analysis.Frontiers in immunology · 2021Pooled it
- Association of hypertension with the severity and fatality of SARS-CoV-2 infection: A meta-analysis.Epidemiology and infection · 2020Pooled it
- The Gut Microbial Metabolite Trimethylamine N-Oxide and Hypertension Risk: A Systematic Review and Dose-Response Meta-analysis.Advances in nutrition (Bethesda, Md.) · 2020Pooled it
- Trial
- Molecular and Cellular Underpinnings of Primary Hypertension: An Integrative Mechanistic Framework.Journal of cellular physiology · 2026Review
- Beyond the guidelines: Vascular function as the central determinant and therapeutic target in hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Review
- Comorbidities and Inflammation: How Chronic Diseases Prime the Host Response in Sepsis.International journal of molecular sciences · 2026Review
- Mean platelet volume is independently associated with systolic and diastolic blood pressure: a retrospective cross-sectional study.BMC cardiovascular disorders · 2026Article
- Association Between Arterial Hypertension and Periodontitis: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Special Issue: Recent Research on Hypertension and Related Complications.International journal of molecular sciences · 2026Article
- The Research Progress in Targeted Therapy for Hypertension via Heat Shock Proteins.International journal of molecular sciences · 2026Review
- Troxerutin is a novel osmotic agent for peritoneal dialysis with protective cardiovascular actions.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026Article
- Shared Genetics of Hypertension and Preeclampsia Converges on Immune Regulation.medRxiv : the preprint server for health sciences · 2026Article
- Evaluation of the Relationship Between the Pan-Immune-Inflammation Score and the Systemic Immune-Inflammation Index and Hypertension: A Retrospective Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Interdialytic blood pressure is independent of weight gain and correlated with serum angiotensin II levels in adults.Physiological reports · 2026Article
- Hypertension-Induced Renal Injury: From Pathophysiology to Therapeutic Perspectives.Biomedicines · 2026Review
154 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
High blood pressure is present in more than one billion adults worldwide and is the most important modifiable risk factor of death resulting from cardiovascular disease. While many factors contribute to the pathogenesis of hypertension, a role of the immune system has been firmly established by a large number of investigations from many laboratories around the world. Immunosuppressive drugs and inhibition of individual cytokines prevent or ameliorate experimental hypertension, and studies in genetically-modified mouse strains have demonstrated that lymphocytes are necessary participants in the development of hypertension and in hypertensive organ injury. Furthermore, immune reactivity may be the driving force of hypertension in autoimmune diseases. Infiltration of immune cells, oxidative stress, and stimulation of the intrarenal angiotensin system are induced by activation of the innate and adaptive immunity. High blood pressure results from the combined effects of inflammation-induced impairment in the pressure natriuresis relationship, dysfunctional vascular relaxation, and overactivity of the sympathetic nervous system. Imbalances between proinflammatory effector responses and anti-inflammatory responses of regulatory T cells to a large extent determine the severity of inflammation. Experimental and human studies have uncovered autoantigens (isoketal-modified proteins and heat shock protein 70) of potential clinical relevance. Further investigations on the immune reactivity in hypertension may result in the identification of new strategies for the treatment of the disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.