Evidence map›Paper›PMID 28566520›Full record

ArticleEMBO reports2017

Mitochondrial permeability transition involves dissociation of F

Massimo Bonora, Claudia Morganti, Giampaolo Morciano, Gaia Pedriali, Magdalena Lebiedzinska-Arciszewska, Giorgio Aquila, Carlotta Giorgi, Paola Rizzo, Gianluca Campo, Roberto Ferrari and 4 more

Open access · greenAbstract read
In one paragraph

Article in EMBO reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed, 2 pooled it
9.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

112 citing papers in PubMed, 2 syntheses or guidelines pooled it, 181 citations in OpenAlex.

  1. Pooled it
  2. FMolecular biology reports · 2023
    Pooled it
  3. Trial
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  5. Article
  6. Review
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  9. Article
  10. CYPD limits HRCell death discovery · 2025
    Article
  11. Review
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  18. Review
  19. The mitochondrial ATP synthase is a negative regulator of the mitochondrial permeability transition pore.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  20. Review

52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 5 countries.

Massimo BonoraDepartment of Morphology, Surgery and Experimental Medicine, Section of General Pathology, University of Ferrara, Ferrara, Italy.ORCID 0000-0002-5752-3318
Claudia MorgantiDepartment of Morphology, Surgery and Experimental Medicine, Section of General Pathology, University of Ferrara, Ferrara, Italy.
Giampaolo MorcianoDepartment of Morphology, Surgery and Experimental Medicine, Section of General Pathology, University of Ferrara, Ferrara, Italy.
Gaia PedrialiDepartment of Morphology, Surgery and Experimental Medicine, Section of General Pathology, University of Ferrara, Ferrara, Italy.
Magdalena Lebiedzinska-ArciszewskaDepartment of Biochemistry, Nencki Institute of Experimental Biology, Warsaw, Poland.
Giorgio AquilaDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
Carlotta GiorgiDepartment of Morphology, Surgery and Experimental Medicine, Section of General Pathology, University of Ferrara, Ferrara, Italy.
Paola RizzoDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
Gianluca CampoCardiovascular Institute, University of Ferrara, Ferrara, Italy.
Roberto FerrariCardiovascular Institute, University of Ferrara, Ferrara, Italy.
Guido KroemerUniversité Paris Descartes/Paris V, Paris, France.
Mariusz R WieckowskiDepartment of Biochemistry, Nencki Institute of Experimental Biology, Warsaw, Poland m.wieckowski@nencki.gov.pl deadoc@vodafone.it paolo.pinton@unife.it.ORCID 0000-0003-0789-4521
Lorenzo GalluzziUniversité Paris Descartes/Paris V, Paris, France m.wieckowski@nencki.gov.pl deadoc@vodafone.it paolo.pinton@unife.it.ORCID 0000-0003-2257-8500
Paolo PintonDepartment of Morphology, Surgery and Experimental Medicine, Section of General Pathology, University of Ferrara, Ferrara, Italy m.wieckowski@nencki.gov.pl deadoc@vodafone.it paolo.pinton@unife.it.ORCID 0000-0001-7108-6508
University of Ferrara · ITDélégation Paris 5 · FRInstytut Biologii Doświadczalnej im. Marcelego Nenckiego · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The impact of the mitochondrial permeability transition (MPT) on cellular physiology is well characterized. In contrast, the composition and mode of action of the permeability transition pore complex (PTPC), the supramolecular entity that initiates MPT, remain to be elucidated. Specifically, the precise contribution of the mitochondrial F

Indexed as

Adenosine TriphosphateAnimalsBiological TransportCyclosporineHEK293 CellsHumansMiceMitochondriaMitochondrial MembranesMitochondrial Membrane Transport ProteinsMitochondrial Proton-Translocating ATPasesNecrosisPermeabilityProtein ConformationProtein MultimerizationRatsAdenosine TriphosphateCyclosporineMitochondrial Membrane Transport ProteinsMitochondrial Proton-Translocating ATPasesATP5G1ATP synthasomecyclosporine ACYPDregulated necrosis

Identifiers

PMID28566520
PMCPMC5494524
OpenAlexW2620432483

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.